Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 7/20 | 0.41 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7172715 | 0.87 | LMNA (0.43) | LMNAPOLBSMN1; SMN2DPP4GBA2 | |
| SCHEMBL21243398 | 0.86 | DPP4 (0.56) | DPP4DPP8DPP9 | |
| SCHEMBL9769179 | 0.82 | GBA2 (0.47) | LMNAPOLBSMN1; SMN2DPP4GBA2 | |
| SCHEMBL30529416 | 0.82 | DPP4 (0.52) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL25508554 | 0.82 | RAB9A (0.36) | DPP4RAB9A | |
| SCHEMBL25505066 | 0.82 | RAB9A (0.36) | RAB9A | |
| SCHEMBL4202768 | 0.79 | POLB (0.46) | LMNAPOLBSMN1; SMN2DPP4GBA2 | |
| SCHEMBL2731646 | 0.79 | POLB (0.46) | LMNAPOLBSMN1; SMN2DPP4GBA2 | |
| SCHEMBL31753062 | 0.79 | LMNA (0.39) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL14144107 | 0.78 | POLB (0.45) | LMNAPOLBSMN1; SMN2GBA2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869032-B8 | PYRIMIDINE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-03-25 | — | — | EP | disclosed |
| EP-1869032-A1 | PYRIMIDINE DERIVATIVES FOR USE AS ANTICANCER AGENTS | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006106307-A1 | PYRIMIDINE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | disclosed |