Sugi Predict

Sugi Predict / Compounds / SCHEMBL3922988

SCHEMBL3922988

SCHEMBL3922988

O=C/C=C/c1ccc(Cl)c(Cl)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.61
▸ XDH P47989 2/20 0.53
▸ KDM4E B2RXH2 1/20 0.48
▸ MAPT P10636 1/20 0.48
▸ PYGL P06737 8/20 0.47
▸ CHAT P28329 1/20 0.47
▸ CCNB2 O95067 1/20 0.47
▸ CDK1 P06493 1/20 0.47
▸ CDK4 P11802 1/20 0.47
▸ CCNB1 P14635 1/20 0.47
▸ CCND1 P24385 1/20 0.47
▸ CCNB3 Q8WWL7 1/20 0.47
▸ TRPA1 O75762 1/20 0.46
▸ LMNA P02545 1/20 0.46
▸ ALOX5 P09917 1/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ KDM4A O75164 1/20 0.46
▸ KDM4B O94953 1/20 0.46
▸ GUSB P08236 1/20 0.42
▸ NPC1 O15118 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2089137 1.00 ALDH1A1 (0.61) ALDH1A1XDHKDM4EMAPTPYGL
SCHEMBL28467646 0.92 ALDH1A1 (0.57) ALDH1A1XDHKDM4EMAPTPYGL
SCHEMBL11464283 0.86 ALDH1A1 (0.58) ALDH1A1PYGLCHATKDM4AKDM4B
SCHEMBL14990172 0.82 XDH (0.48) ALDH1A1XDHKDM4EMAPTPYGL
SCHEMBL18346009 0.82 XDH (0.48) ALDH1A1XDHKDM4EMAPTPYGL
SCHEMBL18346011 0.82 XDH (0.48) ALDH1A1XDHKDM4EMAPTPYGL
SCHEMBL18345531 0.82 XDH (0.48) ALDH1A1XDHKDM4EMAPTCHAT
SCHEMBL14143630 0.82 XDH (0.69) ALDH1A1XDHKDM4EMAPTCCNB2
SCHEMBL18346095 0.82 XDH (0.48) ALDH1A1XDHKDM4EMAPTPYGL
SCHEMBL14989926 0.82 XDH (0.48) ALDH1A1XDHKDM4EMAPTCHAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240217997-A1 NOVEL MEPICIDES AS ANTIMICROBIAL AGENTS GEORGE MASON UNIVERSITY 2024-07-04 — — US disclosed
US-20240217997-A1 NOVEL MEPICIDES AS ANTIMICROBIAL AGENTS GEORGE MASON UNIVERSITY 2024-07-04 — — US disclosed
US-20240217997-A1 NOVEL MEPICIDES AS ANTIMICROBIAL AGENTS GEORGE MASON UNIVERSITY 2024-07-04 — — US disclosed
US-11485710-B2 Heterocyclic amides as kinase inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2022-11-01 — — US disclosed
WO-2022221631-A1 NOVEL MEPICIDES AS ANTIMICROBIAL AGENTS THE GEORGE WASHINGTON UNIVERSITY (US) 2022-10-20 — — WO disclosed
US-20210253532-A1 Heterocyclic Amides as Kinase Inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2021-08-19 — — US disclosed
EP-3298002-B1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2020-12-16 — — EP disclosed
EP-3313837-B1 CARBOLINE ANTIPARASITICS ZOETIS SERVICES LLC (US) 2020-09-09 — — EP disclosed
US-20200165205-A1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2020-05-28 — — US disclosed
US-10570129-B2 Carboline antiparasitics ZOETIS SERVICES LLC (US) 2020-02-25 — — US disclosed
EP-0178633-A2 2-phenylpyrano[2,3-b]pyridines MERRELL DOW PHARMACEUTICALS INC. (US) 1986-04-23 — — EP disclosed
US-4567289-A ANTICHOLESTEROL ANTILIPEMIC MERCK & CO., INC. (US) 1986-01-28 — — US disclosed
US-4487772-A CARDIOTONIC AGENTS OTSUKA PHARMACEUTICAL CO. LTD. (JP) 1984-12-11 — — US disclosed
US-4468402-A Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1984-08-28 — — US disclosed
US-4459422-A Substituted pyranone inhibitors of cholesterol synthesis MERCK & CO., INC. (US) 1984-07-10 — — US disclosed
US-4454130-A CARDIOTONIC, HYPOTENSIVE AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1984-06-12 — — US disclosed
US-4375475-A ANTICHOLESTEROL AGENTS MERCK & CO., INC. (US) 1983-03-01 — — US disclosed
US-4352928-A ANTIINFLAMMATORY, HYPOGLYCEMIC, ANTICOAGULANT, ANOREXIGENIC, SEROTONIN EFFEC MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JP) 1982-10-05 — — US disclosed
EP-0024348-A1 Substituted 6-Phenethyl-and phenylethenyl-3,4,5,6-tetrahydro-4-hydroxytetraydropyran-2-ones in the4-R trans stereoisomeric forms and the corresponding dihydroxy acids, process for preparing and pharmaceutical composition comprising them MERCK & CO. INC. (US) 1981-03-04 — — EP disclosed
EP-0022481-A1 5,6-Alkylenepyrimidine derivatives, processes for preparing the same and pharmaceutical compositions Mitsubishi Yuka Pharmaceutical Co., Ltd. (JP) 1981-01-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210253532-A1 Heterocyclic Amides as Kinase Inhibitors MAP3K19, MAP3K20, MAP3K1 ALDH1A1 1576/4885XDH 2717/4885KDM4E 629/4885
US-20240217997-A1 NOVEL MEPICIDES AS ANTIMICROBIAL AGENTS SMPD1, MLYCD, SMPD3 ALDH1A1 3049/4885XDH 905/4885KDM4E 1276/4885
US-11485710-B2 Heterocyclic amides as kinase inhibitors MAP3K19, MAP3K20, MAP3K1 ALDH1A1 1576/4885XDH 2717/4885KDM4E 629/4885
US-10570129-B2 Carboline antiparasitics ADRA1D, DRD1, CHRM1 ALDH1A1 381/4885XDH 2246/4885KDM4E 3087/4885
US-20200165205-A1 HETEROCYCLIC AMIDES AS KINASE INHIBITORS MAP3K19, MAP3K20, MAP3K1 ALDH1A1 1576/4885XDH 2717/4885KDM4E 629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.