Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930074 | 1.00 | POLB (0.46) | POLBHCRTR2MTNR1ALTB4RLTB4R2 | |
| SCHEMBL75403 | 0.84 | HCRTR2 (0.37) | POLBHCRTR2MTNR1ALTB4RLTB4R2 | |
| SCHEMBL30812977 | 0.84 | POLB (0.44) | POLBSSTR4GAASMN1; SMN2 | |
| SCHEMBL9785817 | 0.84 | POLB (0.44) | POLBSSTR4GAASMN1; SMN2 | |
| SCHEMBL28008010 | 0.84 | POLB (0.44) | POLBMTNR1AGABRA1GABRB2KMT2A | |
| SCHEMBL27594439 | 0.83 | HCRTR2 (0.40) | HCRTR2LTB4RLTB4R2SSTR4CYP19A1 | |
| SCHEMBL19719096 | 0.83 | HTR2B (0.41) | POLBHCRTR2MTNR1ALTB4RLTB4R2 | |
| SCHEMBL11870882 | 0.80 | SSTR4 (0.38) | HCRTR2LTB4RLTB4R2SSTR4CYP19A1 | |
| SCHEMBL10444322 | 0.80 | MTNR1A (0.34) | POLBHCRTR2MTNR1ACYP3A4KMT2A | |
| SCHEMBL31460771 | 0.80 | HCRTR2 (0.49) | HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166114-A | Cyclic tetramer compounds as proprotein convertase subtilisin/KEXIN 9 type (PCSK9) inhibitors for the treatment of metabolic disorders | 诺华股份有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-104507921-A | Benzocyclobutene derivative and preparation method and pharmaceutical application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2015-04-08 | — | — | CN | disclosed |
| EP-2041123-A2 | FUSED CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008001931-A2 | FUSED CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-03 | — | — | WO | disclosed |
| US-4720559-A | Certain 2,3-dihydobenzofuran-3-yl acetic acids and their method of preparation | EASTMAN KODAK COMPANY (US) | 1988-01-19 | — | — | US | disclosed |