Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.54 |
| ▸ | THRA | P10827 | 15/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522420 | 0.89 | THRB (0.55) | THRBTHRAAKR1C2KDM4EALDH1A1 | |
| SCHEMBL3995101 | 0.86 | THRB (0.56) | THRBTHRAAKR1C2 | |
| SCHEMBL4536453 | 0.79 | MAPT (0.43) | THRBKDM4EALDH1A1HPGD | |
| SCHEMBL5858114 | 0.78 | THRB (0.53) | THRBTHRAPPARG | |
| SCHEMBL1684557 | 0.77 | KDM4E (0.70) | THRBAKR1C2PPARGKDM4EALDH1A1 | |
| SCHEMBL6514462 | 0.76 | THRA (0.73) | THRBTHRA | |
| SCHEMBL5858126 | 0.76 | THRB (0.53) | THRBTHRAPPARGALDH1A1HPGD | |
| SCHEMBL6862010 | 0.76 | KDM4E (0.53) | THRBTHRAKDM4E | |
| SCHEMBL3990206 | 0.76 | THRA (0.48) | THRBTHRAPPARG | |
| SCHEMBL4528319 | 0.75 | THRB (0.55) | THRBTHRAAKR1C2PPARGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | KARO BIO AB (SE) | 2009-09-17 | — | — | US | disclosed |
| EP-2035377-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007134864-A1 | INDOLE DERIVATIVES AND THEIR USE AS THYROID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | TSHR, TRHR, THRA | THRB 4/4885THRA 3/4885AKR1C2 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.