Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924708 | 0.79 | THRB (0.54) | KDM4EALDH1A1HPGDTHRB | |
| SCHEMBL28364130 | 0.78 | AHR (0.52) | MAPTAHRKDM4EALDH1A1HPGD | |
| SCHEMBL4522420 | 0.77 | THRB (0.55) | MAPTKDM4EALDH1A1HPGDTHRB | |
| SCHEMBL4374342 | 0.74 | ALDH1A1 (0.68) | MAPTKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL17444608 | 0.72 | KDM4E (0.65) | MAPTKDM4EALDH1A1HPGDTHRB | |
| SCHEMBL18889429 | 0.71 | AHR (0.40) | MAPTAHRKDM4EALDH1A1HPGD | |
| SCHEMBL18906772 | 0.71 | ALDH1A1 (0.44) | MAPTAHRKDM4EALDH1A1HPGD | |
| SCHEMBL18262987 | 0.70 | HCRTR1 (0.52) | MAPTKDM4EALDH1A1HPGDTHRB | |
| SCHEMBL30547021 | 0.70 | HPGD (0.55) | MAPTAHRKDM4EALDH1A1HPGD | |
| SCHEMBL410289 | 0.70 | HPGD (0.55) | MAPTAHRKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |