Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | GRN | P28799 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95749 | 0.82 | NR1H4 (0.70) | NR1H4TP53POLBNOTUML3MBTL1 | |
| SCHEMBL3927703 | 0.81 | HPGD (0.59) | TP53POLBNOTUML3MBTL1KDM4E | |
| SCHEMBL28508820 | 0.80 | KIF11 (0.53) | TP53POLBNOTUML3MBTL1KIF11 | |
| SCHEMBL4947602 | 0.78 | NPC1 (0.59) | TP53NOTUML3MBTL1RAB9ANPC1 | |
| SCHEMBL10084724 | 0.76 | KIF11 (0.49) | TP53POLBNOTUML3MBTL1KIF11 | |
| SCHEMBL21303538 | 0.75 | NPC1 (0.54) | TP53NOTUML3MBTL1KDM4ERAB9A | |
| SCHEMBL3929965 | 0.75 | NPC1 (0.58) | TP53POLBKIF11KDM4ERAB9A | |
| SCHEMBL3938068 | 0.74 | RAB9A (0.50) | TP53NOTUML3MBTL1RAB9ANPC1 | |
| SCHEMBL6164691 | 0.74 | CYP4F2 (0.53) | POLBKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL25094157 | 0.74 | KIF11 (0.50) | TP53POLBNOTUML3MBTL1KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043644-A1 | NF- B INHIBITOR | Otsuka Pharmaceutical Co., Ltd. (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008010601-A1 | NF- ϰB INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-01-24 | — | — | WO | disclosed |