Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438957 | 0.86 | NOTUM (0.47) | NOTUMRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL29541595 | 0.83 | NOTUM (0.52) | NOTUMRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL5306564 | 0.76 | NOTUM (0.53) | NOTUMRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL7832181 | 0.75 | MAPT (0.47) | CYP1A2CYP19A1CYP2C9CYP2C19S1PR1 | |
| SCHEMBL30624472 | 0.75 | MAPT (0.47) | CYP1A2CYP19A1CYP2C9CYP2C19S1PR1 | |
| SCHEMBL4303038 | 0.73 | ALDH1A1 (0.55) | RAB9ANPC1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL9768763 | 0.73 | NOTUM (0.77) | NOTUMRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL2556889 | 0.72 | RAB9A (0.65) | NOTUMRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL3867296 | 0.72 | NOTUM (0.63) | NOTUMRAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL2278361 | 0.70 | MEN1 (0.51) | NOTUMRAB9ANPC1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612067-B2 | Imidazopyridazine compounds | ELI LILLY AND COMPANY (US) | 2009-11-03 | — | — | US | disclosed |
| EP-1869049-B1 | IMIDAZOPYRIDAZINE COMPOUNDS | LILLY CO ELI (US) | 2009-03-04 | — | — | EP | disclosed |
| US-20080113978-A1 | Imidazopyridazine Compounds | ELI LILLY AND COMPANY | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113978-A1 | Imidazopyridazine Compounds | CRHR1, CRH, CRHR2 | NOTUM 4740/4885RAB9A 2305/4885NPC1 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.