Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAT2A | P31153 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788409 | 0.87 | TSPO (0.44) | TSPOMAT2ACYP2C19 | |
| SCHEMBL3922929 | 0.86 | ATM (0.38) | TSPOJAK1 | |
| SCHEMBL3930905 | 0.81 | POLB (0.48) | TSPOCYP2C19ALPL | |
| SCHEMBL4843555 | 0.81 | TSPO (0.63) | TSPOMAT2ACYP2C19 | |
| SCHEMBL3923385 | 0.81 | ALPL (0.45) | ALPL | |
| SCHEMBL7003823 | 0.76 | TSPO (0.71) | TSPO | |
| SCHEMBL7626011 | 0.75 | TSPO (0.64) | TSPO | |
| SCHEMBL3933595 | 0.75 | TSPO (0.59) | TSPOGAA | |
| Hydrochloric Acid SCHEMBL3927977 | 0.75 | TSPO (0.58) | TSPOGAA | |
| SCHEMBL3920697 | 0.75 | TSPO (0.55) | TSPOGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275576-A1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2009-11-05 | — | — | US | disclosed |
| US-7569567-B2 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use | SANOFI-AVENTIS (FR) | 2009-08-04 | — | — | US | disclosed |
| US-20080249098-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide Derivatives, Their Preparation and Therapeutic Use | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | US | disclosed |
| US-7402682-B2 | 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use | SANOFI-AVENTIS (FR) | 2008-07-22 | — | — | US | disclosed |
| EP-1458721-B1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2006-11-22 | — | — | EP | disclosed |
| US-20060241116-A1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2006-10-26 | — | — | US | disclosed |
| US-7109194-B2 | 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use | SANOFI-AVENTIS (FR) | 2006-09-19 | — | — | US | disclosed |
| US-20050096321-A1 | 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use | SANOFI (FR) | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241116-A1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | HTR3C, TPH1, IDO1 | TSPO 1826/4885GAA 3064/4885MAT2A 2281/4885 |
| US-20050096321-A1 | 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use | HTR3C, CYP3A43, IDO1 | TSPO 1918/4885GAA 2875/4885MAT2A 2779/4885 |
| US-20090275576-A1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | HTR3C, TPH1, IDO1 | TSPO 1826/4885GAA 3064/4885MAT2A 2281/4885 |
| US-20080249098-A1 | 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide Derivatives, Their Preparation and Therapeutic Use | HTR3C, TPH1, IDO1 | TSPO 1826/4885GAA 3064/4885MAT2A 2281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.