Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 16/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.40 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3422554 | 0.73 | EGLN1 (0.66) | EGLN1EGLN3OGFOD1EGLN2HIF1AN | |
| SCHEMBL4742597 | 0.72 | EGLN1 (0.43) | EGLN1EGLN3OGFOD1EGLN2HIF1AN | |
| SCHEMBL3917509 | 0.72 | EGLN1 (0.70) | EGLN1EGLN3OGFOD1EGLN2HIF1AN | |
| SCHEMBL4740471 | 0.70 | EGLN1 (0.42) | EGLN1EGLN3OGFOD1EGLN2HIF1AN | |
| SCHEMBL4742622 | 0.68 | EGLN1 (0.42) | EGLN1EGLN3ALDH1A1LMNA | |
| SCHEMBL3926482 | 0.68 | EGLN1 (0.58) | EGLN1EGLN3EGLN2 | |
| SCHEMBL3421207 | 0.63 | SLC22A12 (0.54) | MEN1ALDH1A1LMNAKMT2AAPEX1 | |
| SCHEMBL13908269 | 0.62 | EGLN1 (0.43) | EGLN1EGLN3OGFOD1EGLN2HIF1AN | |
| SCHEMBL4075882 | 0.62 | EGLN1 (0.48) | EGLN1EGLN3EGLN2APEX1 | |
| SCHEMBL3920217 | 0.61 | EGLN1 (0.66) | EGLN1EGLN3OGFOD1EGLN2HIF1AN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037922-A2 | PROLYL HYDROXYLASE INHIBITORS | SmithKline Beecham Corporation (US) | 2009-03-25 | — | — | EP | claimed |
| WO-2007150011-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-27 | — | — | WO | claimed |
| EP-2037922-A2 | PROLYL HYDROXYLASE INHIBITORS | SmithKline Beecham Corporation (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007150011-A2 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-12-27 | — | — | WO | disclosed |