Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.58 |
| ▸ | LAP3 | P28838 | 4/20 | 0.57 |
| ▸ | ANPEP | P15144 | 3/20 | 0.51 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.51 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.51 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.48 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659671 | 1.00 | LTA4H (0.58) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL2848679 | 1.00 | LTA4H (0.58) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL3915987 | 1.00 | LTA4H (0.58) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL4730834 | 0.88 | ITGA4 (0.48) | LTA4HLAP3ANPEPITGA4ITGB7 | |
| SCHEMBL9052981 | 0.87 | ITGA4 (0.45) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL11027685 | 0.85 | SLC7A5 (0.46) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL8770458 | 0.85 | LTA4H (0.46) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL5707507 | 0.85 | METAP2 (0.58) | LTA4HLAP3ANPEPITGA4ITGB7 | |
| SCHEMBL8144508 | 0.85 | METAP2 (0.58) | LTA4HLAP3ANPEPITGA4ITGB7 | |
| SCHEMBL6339522 | 0.84 | LTA4H (0.77) | LTA4HLAP3ANPEPRNPEPDNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084448-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-12-27 | — | — | US | disclosed |
| US-20090181928-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-07-16 | — | — | US | disclosed |
| EP-2038267-A2 | THIADIAZOLIDINONE INHIBITORS OF PTPASE | Novartis AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007115058-A2 | THIADIAZOLIDINONE INHIBITORS OF PTPASE | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |
| US-5736517-A | ADMINISTERING TO TREAT COLON, PROSTATE OR BREAST CANCER | BIOMEASURE, INC. (US) | 1998-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181928-A1 | ORGANIC COMPOUNDS | PTPRS, PTPRO, PTPRC | LTA4H 1254/4885LAP3 2133/4885ANPEP 3457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.