Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | LAP3 | P28838 | 3/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.40 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089396 | 0.87 | LAP3 (0.60) | LTA4HLAP3P2RX7GAACYP2D6 | |
| SCHEMBL11029575 | 0.87 | LAP3 (0.60) | LTA4HLAP3P2RX7GAACYP2D6 | |
| SCHEMBL9476890 | 0.87 | LAP3 (0.60) | LTA4HLAP3P2RX7GAACYP2D6 | |
| SCHEMBL6358444 | 0.86 | GAA (0.46) | LTA4HLAP3GAACYP2D6MAPK1 | |
| SCHEMBL4659671 | 0.85 | LTA4H (0.58) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL3927263 | 0.85 | LTA4H (0.58) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL2848679 | 0.85 | LTA4H (0.58) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL3915987 | 0.85 | LTA4H (0.58) | LTA4HLAP3ANPEPRNPEPDNPEP | |
| SCHEMBL11025627 | 0.84 | LAP3 (0.58) | LTA4HLAP3P2RX7GAACYP2D6 | |
| SCHEMBL8770455 | 0.81 | P2RX7 (0.43) | P2RX7GAALMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0585397-B1 | BOMBESIN ANALOGS | MERRELL PHARMA INC (US) | 1997-08-06 | — | — | EP | disclosed |