Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | TTR | P02766 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL437186 | 0.75 | KMT2A (0.51) | KMT2AMEN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6589927 | 0.75 | MAOB (0.49) | KDM4EALDH1A1MAPTMAOAMAOB | |
| SCHEMBL16448788 | 0.74 | PIM1 (0.51) | KMT2AMEN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL13080558 | 0.74 | KDM4E (0.50) | KMT2AMEN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL32691417 | 0.71 | KMT2A (0.44) | KMT2AMEN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL4247045 | 0.70 | KDM4E (0.54) | KMT2AMEN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL29972769 | 0.70 | KDM4E (0.54) | KMT2AMEN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL29954829 | 0.70 | PTPN1 (0.61) | KDM4EALDH1A1HSD17B10HPGDTTR | |
| SCHEMBL13524013 | 0.70 | PIM1 (0.54) | KMT2AMEN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL1861100 | 0.70 | PTPN1 (0.61) | KDM4EALDH1A1HSD17B10HPGDTTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2248812-B1 | FUSED CYCLIC COMPOUNDS AS GPR40 RECEPTOR MODULATORS | TAKEDA PHARMACEUTICAL (JP) | 2013-12-25 | — | — | EP | disclosed |
| CN-103083307-A | Fused ring compound | TAKEDA PHARMACEUTICAL | 2013-05-08 | — | — | CN | disclosed |
| CN-103070854-A | Fused ring compound | TAKEDA PHARMACEUTICAL | 2013-05-01 | — | — | CN | disclosed |
| EP-2041123-A2 | FUSED CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008001931-A2 | FUSED CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-01-03 | — | — | WO | disclosed |