SCHEMBL4247045

SCHEMBL4247045

Oc1ccc2c(O)coc2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.54
ALDH1A1 P00352 7/20 0.54
SMN1; SMN2 Q16637 5/20 0.54
HSD17B10 Q99714 5/20 0.54
MAPT P10636 3/20 0.54
LMNA P02545 2/20 0.54
ALOX15 P16050 1/20 0.54
HTT P42858 1/20 0.54
NPC1 O15118 4/20 0.53
RAB9A P51151 4/20 0.53
HPGD P15428 4/20 0.53
ESR1 P03372 2/20 0.53
ESR2 Q92731 2/20 0.53
CYP3A4 P08684 2/20 0.53
CA12 O43570 1/20 0.53
AKR1B10 O60218 1/20 0.53
TTR P02766 1/20 0.53
TP53 P04637 1/20 0.53
ALDH2 P05091 1/20 0.53
CYP1A2 P05177 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29972769 1.00 KDM4E (0.54) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT
SCHEMBL11412845 0.84 KDM4E (0.65) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT
SCHEMBL1400551 0.78 KDM4E (0.57) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT
SCHEMBL4416630 0.78 ALOX15 (0.37) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT
SCHEMBL742927 0.75 PIM1 (0.55) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT
SCHEMBL29737520 0.74 KDM4E (0.72) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT
SCHEMBL72610 0.74 KDM4E (0.72) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT
SCHEMBL31134786 0.74 KDM4E (0.72) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT
SCHEMBL204082 0.74 PIM1 (0.54) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT
SCHEMBL15675971 0.74 KDM4E (0.48) KDM4EALDH1A1SMN1; SMN2HSD17B10MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114846082-B Resin composition and film 株式会社钟化 2024-07-12 CN disclosed
WO-2023100589-A1 FLUORO RUBBER CROSSLINKING COMPOSITION AND MOLDED ARTICLE ダイキン工業株式会社 2023-06-08 WO disclosed
US-20220282089-A1 RESIN COMPOSITION AND FILM KANEKA CORPORATION (JP) 2022-09-08 US disclosed
CN-114846082-A Resin composition and film 株式会社钟化 2022-08-02 CN disclosed
WO-2021132279-A1 RESIN COMPOSITION AND FILM 株式会社カネカ 2021-07-01 WO disclosed
CN-105051008-B Guanidinobenzoic acid ester compounds 武田药品工业株式会社 2018-05-29 CN disclosed
EP-2831174-B1 POLYETHERIMIDE POLYCARBONATE BLENDS SABIC GLOBAL TECHNOLOGIES BV (NL) 2018-03-14 EP disclosed
US-9228082-B2 Polyetherimide polycarbonate blends SABIC GLOBAL TECHNOLOGIES B.V. (NL) 2016-01-05 US disclosed
EP-2831174-A1 POLYETHERIMIDE POLYCARBONATE BLENDS SABIC Innovative Plastics IP B.V. (NL) 2015-02-04 EP disclosed
US-8921438-B2 Polyetherimide polycarbonate blends SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2014-12-30 US disclosed
US-20140228462-A1 POLYETHERIMIDE POLYCARBONATE BLENDS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2014-08-14 US disclosed
US-20130261202-A1 POLYETHERIMIDE POLYCARBONATE BLENDS SABIC INNOVATIVE PLASTICS IP B.V. (NE) 2013-10-03 US disclosed
WO-2013148759-A1 POLYETHERIMIDE POLYCARBONATE BLENDS SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2013-10-03 WO disclosed
US-20100292208-A1 COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE JANSSEN PHARMACEUTICA NV (BE) 2010-11-18 US disclosed
US-7556902-B2 Aromatic polyester resin, and electrophotographic photoconductor and image forming apparatus using thereof RICOH COMPANY, LTD. (JP) 2009-07-07 US disclosed
US-7348113-B2 Electrophotographic photoconductor comprising a polycarbonate resin having a dihydroxy diphenyl ether unit RICOH COMPANY, LTD. (JP) 2008-03-25 US disclosed
US-20060046169-A1 Aromatic polyester resin, and electrophotographic photoconductor and image forming apparatus using thereof RICOH COMPANY, LTD. (JP) 2006-03-02 US disclosed
US-20050106483-A1 Aromatic polycarbonate resin, electrophotographic photoconductor, dihydroxy diphenyl ether compound, and process of manufacturing dihydroxy diphenyl ether compound RICOH COMPANY, LTD. (JP) 2005-05-19 US disclosed
US-6018014-A PRESCRIBED DIOL MONOMER HAS STRUCTURE HYDROXY-(ARYLENE)-(2-(AMINOARYL OR HETEROCYCLE)VINYL)-(ARYLENE)-HYDROXYL;USEFUL FOR A CHARGE-TRANSPORT POLYMER MATERIAL FOR AN ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEDIUM RICOH COMPANY, LTD. (JP) 2000-01-25 US disclosed
US-5840454-A Aromatic polycarbonate and electrophotographic photosensitive medium using same RICOH COMPANY, LTD. (JP) 1998-11-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100292208-A1 COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE LTA4H, LTC4S, LTB4R KDM4E 2435/4885ALDH1A1 1950/4885SMN1; SMN2 4691/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.