Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 4/20 | 0.43 |
| ▸ | ADH1A | P07327 | 4/20 | 0.43 |
| ▸ | ADH1C | P00326 | 3/20 | 0.40 |
| ▸ | ADH7 | P40394 | 2/20 | 0.40 |
| ▸ | ADH4 | P08319 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926638 | 0.89 | ADH1B (0.47) | ADH1BADH1AADH1CADH7ADH4 | |
| SCHEMBL1781920 | 0.88 | ADH1B (0.52) | ADH1BADH1AADH1CADH7ADH4 | |
| SCHEMBL172647 | 0.85 | ADH1B (0.40) | ADH1BADH1AADH1CADH7ADH4 | |
| Hydrochloric Acid SCHEMBL28635747 | 0.79 | GNAO1 (0.55) | GNAI3GNAO1GNAI1 | |
| SCHEMBL21757741 | 0.79 | ADH1B (0.34) | ADH1BADH1AADH1CADH7ADH4 | |
| Hydrochloric Acid SCHEMBL28625285 | 0.79 | GNAO1 (0.55) | GNAI3GNAO1GNAI1 | |
| SCHEMBL28278574 | 0.78 | ADH1B (0.40) | ADH1BADH1AADH1CADH7ADH4 | |
| SCHEMBL22702139 | 0.78 | SMN1; SMN2 (0.34) | SMN1; SMN2EPHX1EPHX2RECQLKDM4E | |
| SCHEMBL2549878 | 0.75 | — | — | |
| SCHEMBL13832821 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925737-B1 | TRICYCLIC COMPOUNDS FOR USE IN THE TREATMENT AND/OR CONTROL OF OBESITY | ZAFGEN INC (US) | 2017-06-14 | — | — | EP | disclosed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |