Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.48 |
| ▸ | CCR5 | P51681 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928324 | 0.91 | PTGDR2 (0.54) | PTGDR2CCR5TDP1 | |
| SCHEMBL4014322 | 0.91 | PTGDR2 (0.55) | PTGDR2CCR5ALDH1A1LMNAPOLB | |
| SCHEMBL3934199 | 0.83 | KDM4E (0.54) | PTGDR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3927913 | 0.81 | CCR5 (0.48) | PTGDR2CCR5POLB | |
| SCHEMBL3928788 | 0.81 | PTGDR2 (0.63) | PTGDR2CCR5ALDH1A1LMNAPOLB | |
| SCHEMBL3930674 | 0.81 | CCR5 (0.55) | CCR5 | |
| SCHEMBL3928362 | 0.81 | CCR5 (0.55) | PTGDR2CCR5ALDH1A1MAPK1 | |
| SCHEMBL3931547 | 0.80 | CCR5 (0.62) | CCR5LMNA | |
| SCHEMBL3939227 | 0.80 | ALDH1A1 (0.49) | PTGDR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3928218 | 0.80 | ALDH1A1 (0.51) | PTGDR2ALDH1A1LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |