Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14367071 | 0.87 | ALDH1A1 (0.54) | ALDH1A1PKMMEN1KMT2APTGDR2 | |
| SCHEMBL3933704 | 0.85 | NPSR1 (0.47) | ALDH1A1PKMMEN1KMT2ARAB9A | |
| SCHEMBL14367624 | 0.84 | ALDH1A1 (0.44) | ALDH1A1PKMMEN1KMT2ARAB9A | |
| SCHEMBL4012562 | 0.79 | CCR5 (0.56) | PTGDR2 | |
| SCHEMBL14367500 | 0.79 | HRH3 (0.44) | PTGDR2FFAR4FFAR1 | |
| SCHEMBL3928669 | 0.74 | RXRA (0.44) | ALDH1A1RXRARXRBRXRGPTGDR2 | |
| SCHEMBL11577822 | 0.73 | RXRA (0.58) | ALDH1A1RXRARXRBRXRGMAPT | |
| SCHEMBL14367628 | 0.73 | MAPK14 (0.42) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL14367070 | 0.71 | ALDH1A1 (0.49) | ALDH1A1PKMMEN1KMT2ARAB9A | |
| SCHEMBL3937875 | 0.70 | NPSR1 (0.48) | ALDH1A1PKMMEN1KMT2APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |