Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 1.00 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1857629 | 0.84 | HSD11B1 (0.73) | HSD11B1AVPR1A | |
| SCHEMBL3940274 | 0.84 | HSD11B1 (0.72) | HSD11B1AVPR1AROCK2 | |
| SCHEMBL4171896 | 0.82 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL1855894 | 0.82 | HSD11B1 (1.00) | HSD11B1AVPR1AROCK2 | |
| SCHEMBL1857917 | 0.80 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL3934266 | 0.79 | HSD11B1 (1.00) | HSD11B1ROCK2 | |
| SCHEMBL3940195 | 0.78 | HSD11B1 (0.78) | HSD11B1ROCK2 | |
| SCHEMBL3929905 | 0.77 | HSD11B1 (0.67) | HSD11B1ROCK2 | |
| SCHEMBL1860157 | 0.77 | HSD11B1 (1.00) | HSD11B1ROCK2 | |
| SCHEMBL1856437 | 0.77 | HSD11B1 (1.00) | HSD11B1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044057-A2 | DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | Sanofi-Aventis (FR) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008000950-A2 | DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE | SANOFI-AVENTIS (FR) | 2008-01-03 | — | — | WO | disclosed |