Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | STAT1 | P42224 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928366 | 0.90 | PKM (0.51) | PKMGAALMNAKDM4EMAOA | |
| SCHEMBL3927929 | 0.79 | GAA (0.56) | PKMGAALMNAKDM4EMAOA | |
| SCHEMBL3925437 | 0.78 | KDM4E (0.51) | PKMGAALMNAKDM4EMAOA | |
| SCHEMBL3929258 | 0.76 | STAT1 (0.54) | PKMGAAKDM4EMAOAHTT | |
| SCHEMBL3928992 | 0.75 | STAT1 (0.49) | PKMGAALMNAKDM4EMAOA | |
| SCHEMBL7098287 | 0.75 | MAOA (0.60) | PKMGAALMNAKDM4EMAOA | |
| SCHEMBL3932017 | 0.73 | ALDH1A1 (0.55) | PKMGAAKDM4EMAOAHTT | |
| SCHEMBL6480929 | 0.72 | PKM (0.62) | PKMGAALMNAKDM4EMAOA | |
| SCHEMBL6491049 | 0.72 | PKM (0.62) | PKMGAALMNAKDM4EMAOA | |
| SCHEMBL3925079 | 0.70 | MEN1 (0.64) | GAALMNAKDM4EMAOAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |