Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 13/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | NQO1 | P15559 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522178 | 0.83 | ALDH1A1 (0.50) | GAAKDM4EALDH1A1POLBNQO1 | |
| SCHEMBL2028247 | 0.83 | ALDH1A1 (0.50) | GAAKDM4EALDH1A1POLBNQO1 | |
| SCHEMBL28719517 | 0.81 | NQO1 (0.55) | ALDH1A1POLBNQO1LMNAKMT2A | |
| SCHEMBL10638322 | 0.81 | NQO1 (0.73) | KDM4EALDH1A1NQO1LMNAKMT2A | |
| SCHEMBL21645801 | 0.79 | GAA (0.62) | GAAKDM4EALDH1A1ALOX15HPGD | |
| SCHEMBL4190488 | 0.79 | GAA (0.62) | GAAKDM4EALDH1A1ALOX15HPGD | |
| SCHEMBL307859 | 0.78 | CA12 (0.60) | GAAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL429446 | 0.78 | GAA (0.52) | GAAKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL15231932 | 0.78 | CA12 (0.56) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL28181695 | 0.76 | GAA (0.59) | GAAKDM4EALDH1A1ALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608947-A4 | METHODS OF GENERATING AND SCREENING FOR PROTEASES WITH ALTERED SPECIFICITY | CATALYST BIOSCIENCES INC (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1608947-A2 | METHODS OF GENERATING AND SCREENIGN FOR PORTEASES WITH ALTERED SPECIFICITY | Catalyst Biosciences (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004031733-A2 | METHODS OF GENERATING AND SCREENIGN FOR PORTEASES WITH ALTERED SPECIFICITY | CATALYST BIOSCIENCES (US) | 2004-04-15 | — | — | WO | disclosed |