Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 11/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931201 | 0.87 | CCR5 (0.52) | CCR5KCNH2 | |
| SCHEMBL3928869 | 0.79 | CCR5 (0.48) | CCR5 | |
| SCHEMBL13929221 | 0.77 | SIGMAR1 (0.48) | CCR5KCNH2 | |
| SCHEMBL13929220 | 0.76 | SIGMAR1 (0.56) | CCR5 | |
| SCHEMBL3931205 | 0.74 | OPRM1 (0.40) | CCR5KCNH2CCR2 | |
| SCHEMBL4260236 | 0.73 | MAPT (0.49) | CCR5DRD2 | |
| SCHEMBL13930630 | 0.73 | MAPT (0.49) | CCR5KCNH2CCR2 | |
| SCHEMBL3931152 | 0.69 | LTA4H (0.50) | HTR2A | |
| SCHEMBL4217001 | 0.66 | SIGMAR1 (0.57) | CCR5 | |
| SCHEMBL4771551 | 0.66 | CCR5 (0.77) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010480-A1 | 1-{2-[(DIPHENYL)AMINO]-ETHYL}-PIPERIDINE-4-CARBOXYLIC ACID BENZYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS CCR5 AGONISTS FOR THE TREATMENT OF IMMUNE AND INFLAMMATORY DISEASES | EUROSCREEN S.A. (BE) | 2009-01-22 | — | — | WO | disclosed |