Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | BCL9 | O00512 | 4/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939617 | 0.89 | KMT2A (0.45) | ALDH1A1KMT2AHSP90AA1MEN1BCL9 | |
| SCHEMBL3941700 | 0.89 | BCL9 (0.54) | ALDH1A1KMT2AMEN1BCL9CTNNB1 | |
| SCHEMBL3929084 | 0.87 | MAPT (0.55) | ALDH1A1KMT2AMEN1BCL9CTNNB1 | |
| SCHEMBL3938045 | 0.87 | MAPT (0.55) | ALDH1A1KMT2AMEN1BCL9CTNNB1 | |
| SCHEMBL3930676 | 0.87 | BCL9 (0.49) | KMT2AMEN1BCL9CTNNB1USP5 | |
| SCHEMBL3932070 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1BCL9CTNNB1 | |
| SCHEMBL4110985 | 0.87 | SMN1; SMN2 (0.48) | KMT2AMEN1BCL9CTNNB1USP5 | |
| SCHEMBL3941517 | 0.87 | MAPT (0.55) | ALDH1A1KMT2AMEN1BCL9CTNNB1 | |
| SCHEMBL14366755 | 0.87 | MEN1 (0.48) | KMT2AMEN1BCL9CTNNB1USP5 | |
| SCHEMBL3937652 | 0.86 | MEN1 (0.50) | ALDH1A1KMT2AMEN1BCL9CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | claimed |
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |