Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932024 | 0.85 | VEGFA (0.51) | ALDH1A1GAAGFERFAAHKDM4E | |
| SCHEMBL3927266 | 0.84 | MCL1 (0.49) | ALDH1A1GAAFAAHKDM4ESMN1; SMN2 | |
| SCHEMBL25244127 | 0.83 | SMN1; SMN2 (0.53) | ALDH1A1FAAHKDM4ESMN1; SMN2POLB | |
| SCHEMBL14367070 | 0.83 | ALDH1A1 (0.49) | ALDH1A1GAAGFERKDM4ESMN1; SMN2 | |
| SCHEMBL3928199 | 0.80 | KDM4E (0.42) | ALDH1A1GAAFAAHKDM4ESMN1; SMN2 | |
| SCHEMBL3929765 | 0.80 | NPSR1 (0.46) | ALDH1A1GAAFAAHKDM4EPOLB | |
| SCHEMBL3939039 | 0.80 | KDM4E (0.41) | ALDH1A1GAAFAAHKDM4EPOLB | |
| SCHEMBL14424032 | 0.77 | ACHE (0.53) | ALDH1A1GAAGFERTSHRMEN1 | |
| SCHEMBL3930964 | 0.77 | ALDH1A1 (0.45) | ALDH1A1GAAGFERKDM4ESMN1; SMN2 | |
| SCHEMBL8145260 | 0.77 | ALDH1A1 (0.68) | ALDH1A1GAAGFERKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |