Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.81 |
| ▸ | CSF1R | P07333 | 11/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942233 | 0.90 | BRAF (1.00) | BRAFCSF1RTSHRMAPK1ALDH1A1 | |
| SCHEMBL3936515 | 0.89 | CSF1R (0.83) | BRAFCSF1RALDH1A1KMT2A | |
| SCHEMBL3937788 | 0.89 | BRAF (0.81) | BRAFCSF1RTSHRMAPK1ALDH1A1 | |
| SCHEMBL3932029 | 0.88 | MAPK1 (0.79) | BRAFCSF1RTSHRMAPK1ALDH1A1 | |
| SCHEMBL3936904 | 0.86 | CSF1R (1.00) | BRAFCSF1RTSHRALDH1A1KMT2A | |
| SCHEMBL3941840 | 0.81 | CSF1R (1.00) | BRAFCSF1R | |
| SCHEMBL1276793 | 0.81 | CSF1R (1.00) | BRAFCSF1RKMT2A | |
| SCHEMBL3938361 | 0.80 | CSF1R (0.84) | BRAFCSF1RTSHRALDH1A1KMT2A | |
| SCHEMBL3934792 | 0.80 | CSF1R (0.70) | BRAFCSF1RTSHRALDH1A1MAPT | |
| SCHEMBL3930070 | 0.79 | CSF1R (1.00) | BRAFCSF1RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |