Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.81 |
| ▸ | TSHR | P16473 | 1/20 | 0.81 |
| ▸ | BRAF | P15056 | 13/20 | 0.78 |
| ▸ | CSF1R | P07333 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | TEK | Q02763 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934338 | 0.90 | NPC1 (0.78) | MAPK1TSHRBRAFCSF1RNPC1 | |
| SCHEMBL3932029 | 0.90 | MAPK1 (0.79) | MAPK1TSHRBRAFCSF1RNPC1 | |
| SCHEMBL3941916 | 0.90 | MAPK1 (0.79) | MAPK1TSHRBRAFCSF1RNPC1 | |
| SCHEMBL3942233 | 0.88 | BRAF (1.00) | MAPK1TSHRBRAFCSF1RTEK | |
| SCHEMBL3942646 | 0.87 | BRAF (0.83) | TSHRBRAFCSF1RRAB9AALDH1A1 | |
| SCHEMBL3935730 | 0.86 | BRAF (1.00) | BRAFCSF1RNPC1RAB9AALDH1A1 | |
| SCHEMBL3933229 | 0.85 | BRAF (0.80) | BRAFCSF1RNPC1RAB9AALDH1A1 | |
| SCHEMBL3945794 | 0.83 | BRAF (0.80) | BRAFCSF1R | |
| SCHEMBL3937779 | 0.82 | BRAF (1.00) | BRAFCSF1R | |
| SCHEMBL3941536 | 0.82 | BRAF (0.79) | TSHRBRAFCSF1RNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |