Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 8/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933705 | 0.84 | THRA (0.43) | PTGDR2FFAR4SLC22A12GAAFFAR1 | |
| SCHEMBL3928669 | 0.84 | RXRA (0.44) | PTGDR2FFAR4SLC22A12GAAFFAR1 | |
| SCHEMBL14367624 | 0.76 | ALDH1A1 (0.44) | PTGDR2GAAALDH1A1TSHR | |
| SCHEMBL8072295 | 0.68 | THRB (0.54) | PTGDR2SLC22A12GAAFFAR1RXRA | |
| SCHEMBL8081319 | 0.67 | FFAR1 (0.61) | FFAR1ALDH1A1TSHRNFKB1TDP1 | |
| SCHEMBL14367071 | 0.66 | ALDH1A1 (0.54) | PTGDR2ALDH1A1TSHR | |
| SCHEMBL969758 | 0.66 | GAA (0.70) | FFAR4SLC22A12GAAALDH1A1TSHR | |
| SCHEMBL30094539 | 0.66 | GAA (0.70) | FFAR4SLC22A12GAAALDH1A1TSHR | |
| SCHEMBL17316865 | 0.65 | FFAR4 (0.51) | FFAR4SLC22A12GAAFFAR1RXRA | |
| SCHEMBL2793815 | 0.65 | FFAR4 (0.74) | FFAR4SLC22A12FFAR1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |