Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930804 | 0.89 | DRD2 (0.46) | ALDH1A1LMNASMN1; SMN2HTTPOLB | |
| SCHEMBL3930618 | 0.89 | ALDH1A1 (0.53) | ALDH1A1HSD17B10LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3941700 | 0.87 | BCL9 (0.54) | ALDH1A1HSD17B10LMNASMN1; SMN2MEN1 | |
| SCHEMBL3939587 | 0.86 | DRD3 (0.47) | ALDH1A1POLB | |
| SCHEMBL3933831 | 0.85 | DRD3 (0.47) | SMN1; SMN2MEN1HTTKMT2A | |
| Chlorobenzene SCHEMBL27747084 | 0.83 | DRD3 (0.39) | ALDH1A1HSD17B10POLB | |
| Ethylbenzene SCHEMBL27747179 | 0.83 | DRD3 (0.41) | ALDH1A1HSD17B10MAPTSMN1; SMN2HTT | |
| Fluorobenzene SCHEMBL27747102 | 0.83 | TSHR (0.41) | ALDH1A1HSD17B10LMNAMEN1KMT2A | |
| 1,2-Dichlorobenzene SCHEMBL27768082 | 0.83 | ALDH1A1 (0.40) | ALDH1A1HSD17B10LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3935721 | 0.82 | PTGDR2 (0.51) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | claimed |
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |