Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 8/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22960551 | 0.87 | SLC7A5 (0.46) | SLC7A5STAT3CA12CA1CA2 | |
| SCHEMBL3789286 | 0.84 | CA12 (0.39) | SLC7A5STAT3CA12CA1CA2 | |
| SCHEMBL521171 | 0.84 | SLC7A5 (0.49) | SLC7A5STAT3CA12CA1CA2 | |
| SCHEMBL899028 | 0.83 | SLC7A5 (0.48) | SLC7A5STAT3CA12CA1CA2 | |
| SCHEMBL5919272 | 0.81 | CA12 (0.49) | SLC7A5STAT3CA12CA1CA2 | |
| SCHEMBL4323915 | 0.80 | ALDH1A1 (0.41) | ALDH1A1TDP1 | |
| SCHEMBL18707121 | 0.79 | SLC7A5 (0.47) | SLC7A5STAT3CA12CA1CA2 | |
| SCHEMBL110296 | 0.79 | SLC7A5 (0.58) | SLC7A5STAT3CA12CA1CA2 | |
| SCHEMBL27408427 | 0.78 | SLC7A5 (0.55) | SLC7A5STAT3CA12CA1CA2 | |
| SCHEMBL3784943 | 0.78 | CA12 (0.33) | SLC7A5STAT3CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250034169-A1 | NOVEL PYRIMIDOPYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2025-01-30 | — | — | US | disclosed |
| EP-4417606-A1 | NOVEL PYRIMIDOPYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023061463-A1 | NOVEL PYRIMIDOPYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | 广东东阳光药业有限公司 | 2023-04-20 | — | — | WO | disclosed |
| CN-115974896-A | Novel pyrimidopyridine compounds, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2023-04-18 | — | — | CN | disclosed |
| US-20190352300-A1 | PYRROLOPYRIMIDINE ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | ACLARIS THERAPEUTICS, INC. (US) | 2019-11-21 | — | — | US | disclosed |
| US-10329270-B2 | Heteroaryl compounds as BTK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2019-06-25 | — | — | US | disclosed |
| US-10316038-B2 | Pyrrolopyrimidine ITK inhibitors for treating inflammation and cancer | ACLARIS THERAPEUTICS, INC. (US) | 2019-06-11 | — | — | US | disclosed |
| EP-3060550-B1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |
| US-20190106439-A1 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | CONFLUENCE LIFE SCIENCES, INC. | 2019-04-11 | — | — | US | disclosed |
| US-10150783-B2 | Heterocyclic ITK inhibitors for treating inflammation and cancer | ACLARIS THERAPEUTICS, INC. (US) | 2018-12-11 | — | — | US | disclosed |
| US-8101602-B2 | Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors | Kudos Pharmaceuticals, Ltd. (GB) | 2012-01-24 | — | — | US | disclosed |
| US-20110124638-A1 | Pyrido-, Pyrazo- and Pyrimido-Pyrimidine Derivatives as mTOR Inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2011-05-26 | — | — | US | disclosed |
| US-7902189-B2 | antitumor agent, anticarcinogenic agents; 7-Chloro-2-((2S,6R)-2,6-dimethyl-morpholin-4-yl)-4-morpholin-4-yl-pyrido[2,3-d]pyrimidine; inhibitors of mTOR kinase | ASTRAZENECA AB (SE) | 2011-03-08 | — | — | US | disclosed |
| US-7723369-B2 | Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-20100113331-A1 | Substituted Imidazole Derivatives, Compositions, and Methods of Use as PtPase Inhibitors | TRANSTECH PHARMA, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| EP-1991544-A2 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS PTPASE INHIBITORS | Transtech Pharma, Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| US-20080194546-A1 | Pyrido-, Pyrazo- and Pyrimido-Pyrimidine Derivatives as mTOR Inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-08-14 | — | — | US | disclosed |
| US-20080081809-A1 | Novel Compounds | KUDOS PHARMACEUTICALS LIMITED (GB) | 2008-04-03 | — | — | US | disclosed |
| US-20070191385-A1 | Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors | VTV THERAPEUTICS LLC | 2007-08-16 | — | — | US | disclosed |
| WO-2007089857-A2 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS PTPASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106439-A1 | HETEROCYCLIC ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | ITK, NFKBIA, TNNI3K | SLC7A5 4716/4885STAT3 830/4885CA12 4814/4885 |
| US-10316038-B2 | Pyrrolopyrimidine ITK inhibitors for treating inflammation and cancer | ITK, PDXK, WEE1 | SLC7A5 4362/4885STAT3 1860/4885CA12 4864/4885 |
| US-20070191385-A1 | Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors | PTP4A1, PTPRJ, PTP4A2 | SLC7A5 3532/4885STAT3 1993/4885CA12 3603/4885 |
| US-20250034169-A1 | NOVEL PYRIMIDOPYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF | KRAS, NRAS, TP53 | SLC7A5 948/4885STAT3 920/4885CA12 4332/4885 |
| US-20100113331-A1 | Substituted Imidazole Derivatives, Compositions, and Methods of Use as PtPase Inhibitors | PTP4A1, PTPRJ, PTP4A2 | SLC7A5 3532/4885STAT3 1993/4885CA12 3603/4885 |
| US-20190352300-A1 | PYRROLOPYRIMIDINE ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER | ITK, PDXK, WEE1 | SLC7A5 4362/4885STAT3 1860/4885CA12 4864/4885 |
| US-10150783-B2 | Heterocyclic ITK inhibitors for treating inflammation and cancer | ITK, NFKBIA, TNNI3K | SLC7A5 4716/4885STAT3 830/4885CA12 4814/4885 |
| US-20110124638-A1 | Pyrido-, Pyrazo- and Pyrimido-Pyrimidine Derivatives as mTOR Inhibitors | MTOR, RICTOR, RPTOR | SLC7A5 1252/4885STAT3 537/4885CA12 4844/4885 |
| US-20080081809-A1 | Novel Compounds | SLC10A1, ABCB11, PKD1 | SLC7A5 1187/4885STAT3 364/4885CA12 740/4885 |
| US-10329270-B2 | Heteroaryl compounds as BTK inhibitors and uses thereof | BTK, SYK, LCK | SLC7A5 2348/4885STAT3 715/4885CA12 4872/4885 |
| US-20080194546-A1 | Pyrido-, Pyrazo- and Pyrimido-Pyrimidine Derivatives as mTOR Inhibitors | RPS6KB1, RPS6KA1, RPS3A | SLC7A5 482/4885STAT3 3483/4885CA12 4878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.