Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.73 |
| ▸ | HTR2B | P41595 | 4/20 | 0.73 |
| ▸ | PNMT | P11086 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 7/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5455774 | 0.84 | HTR2C (1.00) | HTR2CHTR2BPNMTHTR6 | |
| SCHEMBL4615894 | 0.84 | DPP4 (0.65) | HTR2CHTR2BPNMTCA12CA1 | |
| SCHEMBL8509022 | 0.84 | CA2 (0.53) | HTR2CHTR2BPNMTHTR6CA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL11784548 | 0.82 | HTR6 (0.64) | HTR2CHTR2BPNMTHTR6CA12 | |
| SCHEMBL8509309 | 0.80 | CA12 (0.58) | HTR2CHTR2BPNMTHTR6CA12 | |
| SCHEMBL5509514 | 0.79 | HTR6 (0.67) | HTR2CHTR2BHTR6 | |
| SCHEMBL9646810 | 0.79 | CA12 (0.56) | HTR2CHTR2BPNMTCA12CA1 | |
| SCHEMBL315066 | 0.78 | MAOA (0.51) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL316166 | 0.78 | GRM5 (0.54) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL5944522 | 0.78 | PNMT (1.00) | HTR2CHTR2BPNMTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4228262-A | SULFUR COMPOUND ALUMINUM CHLORIDE-TITANIUM CHLORIDE COMPLEX POLYMERIZATION CATALYST | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-10-14 | — | — | US | claimed |
| US-4161461-A | OLEFIN COORDINATION-POLYMERIZATION CATALYST; TRANSITION METAL HALIDE TREATED WITH ORGANIC SULFONE, SULFONAMIDE OR SULFIDE AND GRINDED WITH ALUMINUM AND TITANIUM CHLORIDES | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-07-17 | — | — | US | claimed |
| US-20120088837-A1 | TETRALIN AND INDANE DERIVATIVES AND USES THEREOF | ROCHE PALO ALTO LLC | 2012-04-12 | — | — | US | disclosed |
| US-7981923-B2 | Tetralin and indane derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2011-07-19 | — | — | US | disclosed |
| US-20100130742-A1 | TETRALIN AND INDANE DERIVATIVES AND USES THEREOF | HARRIS III RALPH NEW | 2010-05-27 | — | — | US | disclosed |
| US-4400301-A | COORDINATION CATALYST OF ALUMINUM CHLORIDE, TITANIUM TETRACHLORIDE AND A LEWIS BASE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-08-23 | — | — | US | disclosed |
| US-4354010-A | OLEFIN POLYMERIZATION CATALYST | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-10-12 | — | — | US | disclosed |
| US-4243782-A | POLYMERIZATION CATALYSTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-01-06 | — | — | US | disclosed |
| US-4228262-A | SULFUR COMPOUND ALUMINUM CHLORIDE-TITANIUM CHLORIDE COMPLEX POLYMERIZATION CATALYST | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-10-14 | — | — | US | disclosed |
| US-4193893-A | GRINDING METAL COMPOUND WITH A CARBOXYLIC ACID OR ESTER AND AN ORGANO-LEWIS BASE; POLYMERIZATION CATALYST | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-03-18 | — | — | US | disclosed |
| US-4161461-A | OLEFIN COORDINATION-POLYMERIZATION CATALYST; TRANSITION METAL HALIDE TREATED WITH ORGANIC SULFONE, SULFONAMIDE OR SULFIDE AND GRINDED WITH ALUMINUM AND TITANIUM CHLORIDES | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-07-17 | — | — | US | disclosed |
| US-4111834-A | Process for preparing a transition metal compound and it's use as a component in an olefin polymerization catalyst | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130742-A1 | TETRALIN AND INDANE DERIVATIVES AND USES THEREOF | INSRR, TTN, INSR | HTR2C 1135/4885HTR2B 2062/4885PNMT 2190/4885 |
| US-20120088837-A1 | TETRALIN AND INDANE DERIVATIVES AND USES THEREOF | INSRR, RIF1, TTR | HTR2C 1508/4885HTR2B 2354/4885PNMT 2107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.