Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.50 |
| ▸ | EP300 | Q09472 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185087 | 0.84 | LMNA (0.53) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL3937034 | 0.81 | EP300 (0.58) | CYP4A11CYP4F2EP300SMN1; SMN2HRH1 | |
| SCHEMBL11118808 | 0.78 | ALDH1A1 (0.51) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL27765548 | 0.77 | POLB (0.46) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL1167139 | 0.74 | KMT2A (0.51) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL1865448 | 0.74 | ABHD6 (0.52) | CYP4A11CYP4F2KMT2AMEN1ALDH1A1 | |
| SCHEMBL27787352 | 0.74 | TDP1 (0.51) | KMT2AALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL21961350 | 0.73 | ALDH1A1 (0.44) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL29665356 | 0.73 | LMNA (0.54) | KMT2AMEN1ALDH1A1POLBLMNA | |
| SCHEMBL31710511 | 0.73 | KMT2A (0.49) | KMT2AMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046755-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. Hoffmann-Roche AG (CH) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008012227-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-31 | — | — | WO | disclosed |