Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374261 | 0.85 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9AHTTSTS | |
| SCHEMBL606732 | 0.84 | CTSL (0.52) | MAPTSMN1; SMN2NPC1RAB9ACTSL | |
| SCHEMBL951309 | 0.81 | STS (0.56) | SMN1; SMN2NPC1RAB9ACTSLHTT | |
| SCHEMBL9038044 | 0.81 | STS (0.56) | SMN1; SMN2NPC1RAB9ACTSLHTT | |
| SCHEMBL15626861 | 0.81 | STS (0.56) | SMN1; SMN2NPC1RAB9ACTSLHTT | |
| SCHEMBL24897136 | 0.81 | DRD2 (0.53) | CTSLKMT2AALDH1A1TSHRMEN1 | |
| SCHEMBL2455884 | 0.80 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9AHTTSTS | |
| SCHEMBL24131665 | 0.79 | ALDH1A1 (0.63) | CTSLKMT2AALDH1A1TSHRMEN1 | |
| SCHEMBL25431020 | 0.79 | SIGMAR1 (0.56) | MAPTCTSL | |
| SCHEMBL20481159 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9ACTSLHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010480-A1 | 1-{2-[(DIPHENYL)AMINO]-ETHYL}-PIPERIDINE-4-CARBOXYLIC ACID BENZYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS CCR5 AGONISTS FOR THE TREATMENT OF IMMUNE AND INFLAMMATORY DISEASES | EUROSCREEN S.A. (BE) | 2009-01-22 | — | — | WO | disclosed |