Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | STAT1 | P42224 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932839 | 0.89 | RAB9A (0.53) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3942799 | 0.86 | NPC1 (0.55) | RAB9ANPC1ALDH1A1LMNAKMT2A | |
| SCHEMBL3933582 | 0.80 | GAA (0.49) | MAPTALDH1A1SMN1; SMN2POLBLMNA | |
| SCHEMBL31173466 | 0.78 | USP30 (0.50) | — | |
| SCHEMBL3943769 | 0.76 | DRD2 (0.45) | RAB9AALDH1A1KMT2A | |
| SCHEMBL3933930 | 0.75 | CYP19A1 (0.46) | RAB9ASMN1; SMN2POLB | |
| SCHEMBL11675457 | 0.75 | NAAA (0.51) | NPC1MAPTALDH1A1POLB | |
| SCHEMBL3936324 | 0.75 | EPHX2 (0.45) | MAPTSMN1; SMN2POLBLMNATP53 | |
| Fluorobenzene SCHEMBL27747012 | 0.74 | DRD2 (0.39) | ALDH1A1LMNA | |
| SCHEMBL3933429 | 0.74 | ATM (0.62) | RAB9ANPC1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490001-A | Substituted phenylacetic acids as DP-2 antagonists | ICOS CORP (US) | 2009-07-22 | — | — | CN | disclosed |
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |