Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032374 | 0.78 | CYP1A2 (0.49) | KDM4EMAPTNPC1RAB9ANCF1 | |
| SCHEMBL10640426 | 0.77 | KDM4E (0.38) | KDM4EMAPTNPC1RAB9AKMT2A | |
| SCHEMBL938744 | 0.77 | ALDH1A1 (0.40) | KDM4EMAPTNPC1RAB9ACYP2A6 | |
| SCHEMBL1557837 | 0.76 | MAPT (0.42) | KDM4EMAPTNPC1RAB9AKMT2A | |
| SCHEMBL2187375 | 0.76 | KMT2A (0.42) | KDM4EMAPTNPC1RAB9AKMT2A | |
| SCHEMBL1385432 | 0.75 | ALDH1A1 (0.42) | KDM4EMAPTNPC1RAB9AGLA | |
| SCHEMBL4875674 | 0.74 | MAPT (0.39) | KDM4EMAPTNPC1RAB9AKMT2A | |
| SCHEMBL29923403 | 0.73 | PLAU (0.60) | KDM4EMAPTNPC1RAB9AKMT2A | |
| SCHEMBL199273 | 0.73 | PLAU (0.60) | KDM4EMAPTNPC1RAB9AKMT2A | |
| SCHEMBL5516956 | 0.73 | ESR1 (0.44) | KDM4EMAPTGLAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572913-B2 | Inhibitors of Rho kinase; N-Benzyloxycarbonyl-4-[N''-(tert-butyloxycarbonyl)hydrazino]piperidine; 4-{[N''-(tert-butyloxycarbonyl)-N'-(1'-propyl)]hydrazino}piperidine | BIOAXONE THERAPEUTIQUE INC. (CA) | 2009-08-11 | — | — | US | claimed |
| US-6613776-B2 | Protein serine/threonine kinase inhibitors used for treating diseases such as cancer, diabetes and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED | 2003-09-02 | — | — | US | claimed |
| EP-0302389-A2 | Alpha-unsaturated amines, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1989-02-08 | — | — | EP | claimed |
| CN-115504896-B | Acrylic formate compound for LED photopolymerization, preparation method and application thereof | 湖北固润科技股份有限公司 | 2024-05-07 | — | — | CN | disclosed |
| EP-2845854-B1 | DEUTERATED BENZOPYRAN COMPOUND AND APPLICATION THEREOF | GUANGZHOU INST BIOMED & HEALTH (CN) | 2016-09-21 | — | — | EP | disclosed |
| EP-2845854-A1 | DEUTERATED BENZOPYRAN COMPOUND AND APPLICATION THEREOF | Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences (CN) | 2015-03-11 | — | — | EP | disclosed |
| CN-102741258-A | Compositions and methods of cyclofructans as separating agents | UNIV TEXAS | 2012-10-17 | — | — | CN | disclosed |
| US-7105682-B2 | Substituted amine derivatives and methods of use | AMGEN INC. (US) | 2006-09-12 | — | — | US | disclosed |
| EP-1053241-A1 | NOVEL DIMERIZING AGENTS, THEIR PRODUCTION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999041258-A1 | NOVEL DIMERIZING AGENTS, THEIR PRODUCTION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1999-08-19 | — | — | WO | disclosed |
| US-5491149-A | VIRICIDES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-02-13 | — | — | US | disclosed |
| US-5003097-A | Method for the sulfurization of phosphorous groups in compounds | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1991-03-26 | — | — | US | disclosed |
| EP-0081094-A1 | Substituted omega-amino-carboxymethyldipeptide antihypertensive agents | MERCK & CO. INC. (US) | 1983-06-15 | — | — | EP | disclosed |