Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 7/20 | 0.46 |
| ▸ | CTSS | P25774 | 6/20 | 0.46 |
| ▸ | CTSB | P07858 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263829 | 0.88 | CTSS (0.47) | CTSKCTSSCTSBCTSLSYK | |
| SCHEMBL693223 | 0.87 | SIGMAR1 (0.53) | CA2CTSKCTSSCTSBIDO1 | |
| SCHEMBL731698 | 0.85 | CA2 (0.51) | CA2CTSKCTSSCTSBCTSL | |
| SCHEMBL6414451 | 0.85 | CA2 (0.51) | CA2CTSKCTSSCTSBCTSL | |
| SCHEMBL731697 | 0.85 | CA2 (0.51) | CA2CTSKCTSSCTSBCTSL | |
| SCHEMBL14977016 | 0.84 | SIGMAR1 (0.50) | CA2CTSKCTSSCTSBNQO2 | |
| SCHEMBL730856 | 0.84 | SIGMAR1 (0.50) | CA2CTSKCTSSCTSBNQO2 | |
| SCHEMBL730857 | 0.84 | SIGMAR1 (0.50) | CA2CTSKCTSSCTSBNQO2 | |
| SCHEMBL14987233 | 0.80 | GLS (0.50) | CA2CTSKNQO2POLBIDO1 | |
| SCHEMBL16798316 | 0.80 | NQO2 (0.50) | CA2CTSKNQO2POLBIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041118-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |