Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.67 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL3790707 | 0.97 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL872579 | 0.97 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL2459166 | 0.95 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL27987657 | 0.92 | LMNA (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL27347099 | 0.90 | MEN1 (0.55) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL28318708 | 0.89 | CYP3A4 (0.68) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL339064 | 0.89 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL868978 | 0.89 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL27779128 | 0.89 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL31591121 | 0.88 | MEN1 (0.67) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3721297-B1 | PHOTORESIST STRIPPER COMPOSTION | HENKEL AG & CO KGAA (DE) | 2024-02-07 | — | — | EP | claimed |
| EP-3975992-B1 | GREEN TEA CATECHINS EUTECTIC SYSTEM | HOPITAUX PARIS ASSIST PUBLIQUE (FR) | 2023-07-19 | — | — | EP | claimed |
| US-20220211661-A1 | GREEN TEA CATECHINS EUTECTIC SYSTEM | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (FR) | 2022-07-07 | — | — | US | claimed |
| US-11347149-B2 | Photoresist stripper composition | HENKEL AG & CO. KGAA (DE) | 2022-05-31 | — | — | US | claimed |
| EP-3975992-A1 | GREEN TEA CATECHINS EUTECTIC SYSTEM | ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS (FR) | 2022-04-06 | — | — | EP | claimed |
| EP-3744312-B1 | GREEN TEA CATECHINS EUTECTIC SYSTEM | HOPITAUX PARIS ASSIST PUBLIQUE (FR) | 2022-03-23 | — | — | EP | claimed |
| WO-2020239929-A1 | GREEN TEA CATECHINS EUTECTIC SYSTEM | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (FR) | 2020-12-03 | — | — | WO | claimed |
| EP-3744312-A1 | GREEN TEA CATECHINS EUTECTIC SYSTEM | ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS (FR) | 2020-12-02 | — | — | EP | claimed |
| EP-3721297-A1 | PHOTORESIST STRIPPER COMPOSTION | Henkel AG & Co. KGaA (DE) | 2020-10-14 | — | — | EP | claimed |
| US-20200301284-A1 | PHOTORESIST STRIPPER COMPOSITION | HENKEL AG & CO. KGAA (DE) | 2020-09-24 | — | — | US | claimed |
| US-8679546-B2 | Ruminant feed pellet composition with controlled release of physiologically active substances, and procedure for preparation and use thereof | VALENTINI S.R.L. (IT) | 2014-03-25 | — | — | US | claimed |
| US-8101410-B2 | Selection marker system and method for screening a choline tolerant plant cell | ENTELECHON GMBH (DE) | 2012-01-24 | — | — | US | claimed |
| US-20090170093-A1 | SELECTION MARKER SYSTEM AND METHOD FOR SCREENING A CHOLINE TOLERANT PLANT CELL | ENTELECHON GMBH (DE) | 2009-07-02 | — | — | US | claimed |
| WO-2007065697-A2 | SELECTION MARKER SYSTEM AND METHOD FOR SCREENING A CHOLINE TOLERANT PLANT CELL | ENTELECHON GMBH (DE) | 2007-06-14 | — | — | WO | claimed |
| EP-1795611-A1 | Selection marker system and method for screening a choline tolerant plant cell | Entelechon Gmbh (DE) | 2007-06-13 | — | — | EP | claimed |
| EP-1791532-A2 | COMPOSITION IN MICRO-PELLETS WITH CONTROLLED RELEASE OF PHYSIOLOGICALLY ACTIVE SUBSTANCES, PROCEDURE FOR THEIR PREPARATION AND USE IN THE ZOOTECHNICAL SECTOR | ASCOR CHIMICI S.r.l. (IT) | 2007-06-06 | — | — | EP | claimed |
| WO-2006032958-A2 | COMPOSITION IN MICRO-PELLETS WITH CONTROLLED RELEASE PHYSIOLOGICALLY ACTIVE SUBSTANCE, PROCEDURE FOR THEIR PREPARATION AND USE IN THE ZOOTECHENICAL SECTOR | ASCOR CHIMICI S.R.L. (IT) | 2006-03-30 | — | — | WO | claimed |
| US-20060067984-A1 | Composition in micro-pellets with controlled release of physiologically active substances, procedure for their preparation and use in the zootechnical sector | BALCHEM ITALIA S.R.L. (IT) | 2006-03-30 | — | — | US | claimed |
| US-5972862-A | COMPRISING A FLUORINE-CONTAINING COMPOUND, A WATER-SOLUBLE OR WATER-MISCIBLE ORGANIC SOLVENT, AN ORGANIC ACID, AND A QUATERNARY AMMONIUM SALT | MITSUBISHI GAS CHEMICAL (JP) | 1999-10-26 | — | — | US | claimed |
| CN-1081569-A | agricultural composition for promoting plant photosynthesis | SWALLOW ENTERPRISES CO (HK) | 1994-02-09 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220211661-A1 | GREEN TEA CATECHINS EUTECTIC SYSTEM | TEAD4, TEAD2, TEAD3 | MEN1 1363/4885KMT2A 2520/4885LMNA 1270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.