Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.60 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL393397 | 0.89 | MEN1 (0.67) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL872579 | 0.86 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL27987657 | 0.86 | LMNA (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL3790707 | 0.86 | MEN1 (0.63) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL28318708 | 0.84 | CYP3A4 (0.68) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL339064 | 0.84 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL2459166 | 0.84 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL27779128 | 0.84 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL31591121 | 0.83 | MEN1 (0.67) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL872577 | 0.82 | MEN1 (0.57) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150174160-A1 | METHODS FOR TREATING, DIAGNOSING AND/OR MONITORING PROGRESSION OF OXO ASSOCIATED STATES | PRAVDA JAY (US) | 2015-06-25 | — | — | US | claimed |
| EP-2866565-A2 | METHODS FOR TREATING, DIAGNOSING AND/OR MONITORING PROGRESSION OF OXO ASSOCIATED STATES | Pravda, Jay (US) | 2015-05-06 | — | — | EP | claimed |
| US-20140335205-A1 | MATERIALS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | THERAPEUTIC RES LLC (US) | 2014-11-13 | — | — | US | claimed |
| WO-2014008273-A2 | METHODS FOR TREATING, DIAGNOSING AND/OR MONITORING PROGRESSION OF OXO ASSOCIATED STATES | PRAVDA JAY (US) | 2014-01-09 | — | — | WO | claimed |
| US-20120322773-A1 | MATERIALS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | PRAVDA JAY (US) | 2012-12-20 | — | — | US | claimed |
| US-20100112088-A1 | MATERIALS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | PRAVDA JAY | 2010-05-06 | — | — | US | claimed |
| US-10064877-B2 | Materials and methods for treatment and diagnosis of disorders associated with oxidative stress | THERAPEUTIC RESEARCH, LLC (US) | 2018-09-04 | — | — | US | disclosed |
| US-20170296559-A1 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | THERAPEUTIC RES LLC (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170182067-A1 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | THERAPEUTIC RES LLC (US) | 2017-06-29 | — | — | US | disclosed |
| US-9511049-B2 | Materials and methods for treatment and diagnosis of disorders associated with oxidative stress | THERAPEUTIC RESEARCH LLC (US) | 2016-12-06 | — | — | US | disclosed |
| US-20150174160-A1 | METHODS FOR TREATING, DIAGNOSING AND/OR MONITORING PROGRESSION OF OXO ASSOCIATED STATES | PRAVDA JAY (US) | 2015-06-25 | — | — | US | disclosed |
| EP-2866565-A2 | METHODS FOR TREATING, DIAGNOSING AND/OR MONITORING PROGRESSION OF OXO ASSOCIATED STATES | Pravda, Jay (US) | 2015-05-06 | — | — | EP | disclosed |
| US-20150105356-A1 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | THERAPEUTIC RESEARCH LLC (US) | 2015-04-16 | — | — | US | disclosed |
| EP-2392321-A1 | Combined composition for rectal administration for the treatment of inflammatory bowel disease | Pravda, Jay (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2162125-B1 | Composition for rectal administration combined with an oral alpha-lipoic acid composition for the treatment of inflammatory bowel disease | PRAVDA JAY (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20100184728-A1 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | THERAPEUTIC RESEARCH LLC (US) | 2010-07-22 | — | — | US | disclosed |
| US-20100112088-A1 | MATERIALS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | PRAVDA JAY | 2010-05-06 | — | — | US | disclosed |
| EP-2162125-A2 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | Pravda, Jay (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008156671-A2 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | PRAVDA JAY (US) | 2008-12-24 | — | — | WO | disclosed |
| US-7312243-B1 | Materials and methods for treatment of gastrointestinal disorders | THERAPEUTIC RESEARCH, LLC | 2007-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10064877-B2 | Materials and methods for treatment and diagnosis of disorders associated with oxidative stress | NR3C1, GSTA1, LTC4S | MEN1 4754/4885KMT2A 3870/4885LMNA 3822/4885 |
| US-20100184728-A1 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | NR3C1, GSTA1, LTC4S | MEN1 4754/4885KMT2A 3870/4885LMNA 3822/4885 |
| US-20120322773-A1 | MATERIALS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | LPO, ALOX15B, ALOX15 | MEN1 3706/4885KMT2A 721/4885LMNA 1762/4885 |
| US-20170296559-A1 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | NR3C1, GSTA1, LTC4S | MEN1 4754/4885KMT2A 3870/4885LMNA 3822/4885 |
| US-20150105356-A1 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | NR3C1, GSTA1, LTC4S | MEN1 4754/4885KMT2A 3870/4885LMNA 3822/4885 |
| US-20140335205-A1 | MATERIALS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | TXN, GPX4, TXN2 | MEN1 4690/4885KMT2A 3479/4885LMNA 4303/4885 |
| US-20100112088-A1 | MATERIALS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | TXN, GPX4, TXN2 | MEN1 4690/4885KMT2A 3479/4885LMNA 4303/4885 |
| US-20150174160-A1 | METHODS FOR TREATING, DIAGNOSING AND/OR MONITORING PROGRESSION OF OXO ASSOCIATED STATES | OAT, OTC, HOGA1 | MEN1 3440/4885KMT2A 4117/4885LMNA 3265/4885 |
| US-20170182067-A1 | MATERIALS AND METHODS FOR TREATMENT AND DIAGNOSIS OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS | NR3C1, GSTA1, LTC4S | MEN1 4754/4885KMT2A 3870/4885LMNA 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.