Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ALPL | P05186 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933183 | 0.85 | SMN1; SMN2 (0.71) | KMT2ASMN1; SMN2POLBMAPTCYP11B1 | |
| SCHEMBL26758011 | 0.84 | SMN1; SMN2 (0.74) | KMT2ASMN1; SMN2POLBMAPTNPC1 | |
| SCHEMBL5796376 | 0.84 | SMN1; SMN2 (0.58) | GAAKMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL3937705 | 0.82 | SMN1; SMN2 (0.82) | KMT2ASMN1; SMN2POLBMAPTNPC1 | |
| SCHEMBL3936626 | 0.82 | SMN1; SMN2 (0.71) | KMT2ASMN1; SMN2POLBMAPTNPC1 | |
| SCHEMBL4033553 | 0.82 | SMN1; SMN2 (0.56) | GAAKMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL13163081 | 0.81 | POLB (0.70) | GAAKMT2ASMN1; SMN2POLBMAPT | |
| SCHEMBL3936760 | 0.81 | GAA (0.76) | GAASMN1; SMN2POLBMAPTKDM4E | |
| SCHEMBL5026608 | 0.80 | KMT2A (0.57) | GAAKMT2ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL30322736 | 0.80 | LRRK2 (0.73) | SMN1; SMN2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |