Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.65 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26758011 | 0.88 | SMN1; SMN2 (0.74) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL3933183 | 0.85 | SMN1; SMN2 (0.71) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL3937705 | 0.85 | SMN1; SMN2 (0.82) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL1456273 | 0.84 | MAPT (0.71) | SMN1; SMN2KMT2AMEN1MAPTNPSR1 | |
| SCHEMBL3934052 | 0.82 | GAA (0.69) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL13163904 | 0.81 | CYP11B2 (0.70) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL2568462 | 0.81 | MAPT (0.58) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL6939622 | 0.80 | RXFP1 (0.64) | SMN1; SMN2MAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL7128348 | 0.80 | SMN1; SMN2 (0.72) | SMN1; SMN2CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL3940427 | 0.80 | CYP11B2 (0.71) | CYP11B2CYP11B1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |
| EP-1831198-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067446-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |