Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 1.00 |
| ▸ | CSF1R | P07333 | 3/20 | 0.63 |
| ▸ | TEK | Q02763 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3937788 | 0.90 | BRAF (0.81) | BRAFCSF1RTEKTSHRMAPK1 | |
| SCHEMBL3934096 | 0.90 | BRAF (0.81) | BRAFCSF1RTSHRMAPK1NR1H4 | |
| SCHEMBL3935730 | 0.89 | BRAF (1.00) | BRAFCSF1RALDH1A1KITKDR | |
| SCHEMBL4165366 | 0.88 | MAPK1 (0.81) | BRAFCSF1RTEKTSHRMAPK1 | |
| SCHEMBL3942646 | 0.86 | BRAF (0.83) | BRAFCSF1RTSHRALDH1A1 | |
| SCHEMBL3933229 | 0.84 | BRAF (0.80) | BRAFCSF1RALDH1A1KITKDR | |
| SCHEMBL3937779 | 0.82 | BRAF (1.00) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL1276903 | 0.80 | BRAF (1.00) | BRAFCSF1R | |
| SCHEMBL3945794 | 0.80 | BRAF (0.80) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3942520 | 0.80 | BRAF (1.00) | BRAFCSF1RKITKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |