Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 5/20 | 0.52 |
| ▸ | ITGB7 | P26010 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | YWHAG | P61981 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986153 | 0.79 | ALDH1A1 (0.51) | ALDH1A1GAAGFEREGFRCYP4F2 | |
| SCHEMBL8145260 | 0.73 | ALDH1A1 (0.68) | ALDH1A1GAAGFEREGFRCYP4F2 | |
| SCHEMBL13612621 | 0.73 | ITGA4 (0.45) | ITGA4ITGB7GAAPDCD1CD274 | |
| SCHEMBL27766064 | 0.73 | ALDH1A1 (0.53) | ITGA4ITGB7ALDH1A1GAAGFER | |
| SCHEMBL17475162 | 0.72 | ITGA4 (0.43) | ITGA4ITGB7ALDH1A1GAAGFER | |
| SCHEMBL17475159 | 0.72 | ITGA4 (0.43) | ITGA4ITGB7ALDH1A1GAAGFER | |
| SCHEMBL3933326 | 0.72 | ALDH1A1 (0.55) | ALDH1A1GAAGFEREGFRCYP4F2 | |
| SCHEMBL13605104 | 0.72 | EPHX2 (0.46) | ITGA4ITGB7 | |
| SCHEMBL3934276 | 0.72 | ALDH1A1 (0.46) | ALDH1A1GAAGFEREGFRCYP4F2 | |
| SCHEMBL17761771 | 0.72 | ITGA4 (0.58) | ITGA4ITGB7ALDH1A1PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |