Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935182 | 1.00 | POLB (0.38) | POLBLMNAKDM4EGAAPPIA | |
| SCHEMBL3009389 | 0.74 | LMNA (0.42) | POLBLMNAKDM4EGAAPPIA | |
| SCHEMBL8065818 | 0.73 | POLB (0.44) | POLBLMNAKDM4EGAAPPIA | |
| SCHEMBL15180831 | 0.73 | POLB (0.44) | POLBLMNAKDM4EGAAPPIA | |
| SCHEMBL29365220 | 0.73 | ALDH1A1 (0.56) | POLBLMNAKDM4EGAAPPIA | |
| SCHEMBL180853 | 0.73 | ALDH1A1 (0.56) | POLBLMNAKDM4EGAAPPIA | |
| SCHEMBL587841 | 0.72 | CYP1A2 (0.56) | KDM4EALDH1A1HPGDTDP1MAPT | |
| SCHEMBL9116375 | 0.72 | LMNA (0.36) | POLBLMNAKDM4EGAAALDH1A1 | |
| SCHEMBL9116385 | 0.72 | LMNA (0.36) | POLBLMNAKDM4EGAAALDH1A1 | |
| SCHEMBL11398928 | 0.72 | ESR1 (0.32) | POLBLMNAKDM4EGAAPPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046748-A1 | PHENYLPENTADIENOYL DERIVATIVES AND THEIR USE AS PAR 1 ANTAGONISTS | Pierre Fabre Medicament (FR) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007147822-A1 | PHENYLPENTADIENOYL DERIVATIVES AND THEIR USE AS PAR 1 ANTAGONISTS | PIERRE FABRE MEDICAMENT (FR) | 2007-12-27 | — | — | WO | disclosed |