Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | TCF4 | P15884 | 2/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | P4HB | P07237 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2195246 | 0.86 | RAB9A (0.49) | LOXL2TSHRCYP4F2CYP4A11RAB9A | |
| SCHEMBL2892597 | 0.82 | TSHR (0.53) | LOXL2TSHRCYP4F2CYP4A11TCF4 | |
| SCHEMBL1787501 | 0.82 | ACHE (0.59) | LOXL2TSHRCYP4F2CYP4A11TCF4 | |
| SCHEMBL548002 | 0.80 | TSHR (0.52) | LOXL2TSHRCYP4F2CYP4A11TCF4 | |
| SCHEMBL12065517 | 0.79 | LOXL2 (0.54) | LOXL2TSHRCYP4F2CYP4A11TCF4 | |
| SCHEMBL3933098 | 0.79 | TAS1R3 (0.54) | LOXL2TSHRCYP4F2CYP4A11RAB9A | |
| SCHEMBL29878170 | 0.78 | BRAF (0.47) | LOXL2TSHRCYP4F2CYP4A11RAB9A | |
| SCHEMBL2194184 | 0.78 | LOXL2 (0.46) | LOXL2TSHRCYP4F2CYP4A11TCF4 | |
| SCHEMBL1697911 | 0.78 | BRAF (0.47) | LOXL2TSHRCYP4F2CYP4A11RAB9A | |
| SCHEMBL2159023 | 0.78 | LOXL2 (0.49) | LOXL2TSHRCYP4F2CYP4A11TCF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| EP-1831198-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067446-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |