Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44748 | 0.89 | NOTUM (0.38) | TSHRMAPTHPGDLMNAMAPK1 | |
| SCHEMBL44093 | 0.89 | HDAC1 (0.40) | TSHRHDAC1HDAC8MAPTHPGD | |
| SCHEMBL44767 | 0.86 | MAPK1 (0.40) | TSHRMAPTHPGDLMNAMAPK1 | |
| SCHEMBL44261 | 0.85 | MAPT (0.35) | TSHRMAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL43982 | 0.83 | PDCD1 (0.41) | PDCD1CD274TSHRHDAC1HDAC8 | |
| SCHEMBL43634 | 0.83 | MAPK1 (0.38) | TSHRMAPTHPGDLMNAMAPK1 | |
| SCHEMBL44242 | 0.83 | HPGD (0.39) | TSHRMAPTHPGDLMNASMN1; SMN2 | |
| SCHEMBL44714 | 0.83 | FFAR1 (0.36) | MAPTHPGDLMNASMN1; SMN2PKM | |
| SCHEMBL38269 | 0.82 | L3MBTL1 (0.39) | MAPTHPGDLMNASMN1; SMN2S1PR1 | |
| SCHEMBL43952 | 0.81 | SMPD1 (0.36) | MAPTLMNAS1PR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |