Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39375 | 0.89 | PDCD1 (0.35) | HDAC1HDAC8HDAC2MAPTTSHR | |
| SCHEMBL44767 | 0.86 | MAPK1 (0.40) | MAPTTSHRL3MBTL1LMNANPC1 | |
| SCHEMBL44261 | 0.85 | MAPT (0.35) | MAPTTSHRL3MBTL1LMNANPC1 | |
| SCHEMBL44748 | 0.85 | NOTUM (0.38) | MAPTTSHRL3MBTL1LMNAMAPK1 | |
| SCHEMBL43634 | 0.83 | MAPK1 (0.38) | MAPTTSHRL3MBTL1LMNANPC1 | |
| SCHEMBL38269 | 0.82 | L3MBTL1 (0.39) | MAPTL3MBTL1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL44205 | 0.81 | SMPD1 (0.35) | HPGD | |
| SCHEMBL44714 | 0.81 | FFAR1 (0.36) | MAPTL3MBTL1LMNASMN1; SMN2HPGD | |
| SCHEMBL43952 | 0.80 | SMPD1 (0.36) | MAPTLMNA | |
| SCHEMBL43886 | 0.79 | HDAC6 (0.41) | HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |