Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL6471890 | 0.96 | — | — | |
| Guanidine SCHEMBL392029 | 0.96 | CA1 (0.46) | — | |
| Guanidine SCHEMBL5579267 | 0.93 | CA1 (0.43) | — | |
| Guanidine SCHEMBL3505806 | 0.93 | — | — | |
| Guanidine SCHEMBL8647467 | 0.93 | — | — | |
| Guanidine SCHEMBL23069845 | 0.93 | CA1 (0.50) | — | |
| Guanidine SCHEMBL28279993 | 0.93 | CA1 (0.50) | — | |
| Guanidine SCHEMBL27608132 | 0.93 | CA1 (0.50) | — | |
| Guanidine SCHEMBL2929472 | 0.93 | CA1 (0.50) | — | |
| Guanidine SCHEMBL28942 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 205 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725733-B2 | Polynucleotide encoding NF-YB derived from jatropha and use thereof | OSAKA UNIVERSITY (JP) | 2017-08-08 | — | — | US | disclosed |
| EP-2604686-B1 | HIGHLY FUNCTIONALIZED STEM CELL/PROGENITOR CELL BY APE1 GENE TRANSFECTION | NAT UNIV CORP ASAHIKAWA MEDICAL UNIV (JP) | 2017-07-26 | — | — | EP | disclosed |
| US-9598501-B2 | Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier | NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY (JP) | 2017-03-21 | — | — | US | disclosed |
| US-20170044567-A1 | POLYNUCLEOTIDE ENCODING NF-YB DERIVED FROM JATROPHA AND USE THEREOF | OSAKA UNIVERSITY (JP) | 2017-02-16 | — | — | US | disclosed |
| US-9447426-B2 | Polynucleotide encoding NF-YB derived from jatropha and use thereof | OSAKA UNIVERSITY (JP) | 2016-09-20 | — | — | US | disclosed |
| US-9255278-B2 | Polynucleotide encoding PPAT derived from jatropha and use thereof | SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) | 2016-02-09 | — | — | US | disclosed |
| US-8980272-B2 | Antibody targeting osteoclast-associated protein | SANKYO COMPANY, LIMITED (JP) | 2015-03-17 | — | — | US | disclosed |
| US-8883985-B2 | Antibody-immobilized carrier, method of producing antibody-immobilized carrier, and use of said antibody-immobilized carrier | NATIONAL UNIVERSITY CORPORATION KYOTO INSTITUTE OF TECHNOLOGY (JP) | 2014-11-11 | — | — | US | disclosed |
| US-8759025-B2 | Humanized anti-CD47 antibody | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2014-06-24 | — | — | US | disclosed |
| US-20140030239-A1 | HIGHLY FUNCTIONALIZED STEM CELL/PROGENITOR CELL BY APE1 GENE TRANSFECTION | NATIONAL UNIVERSITY CORPORATION ASAHIKAWA MEDICAL UNIVERSITY (JP) | 2014-01-30 | — | — | US | disclosed |
| EP-0462277-A1 | GLYCOPROTEIN OF HUMAN ORIGIN, PHYSIOLOGICALLY ACTIVE FACTOR COMPRISING THE SAME, AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME AS ACTIVE INGREDIENT | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1991-12-27 | — | — | EP | disclosed |
| EP-0198645-B1 | HUMAN PANCREATIC ELASTASE | SANKYO COMPANY LIMITED (JP) | 1990-11-22 | — | — | EP | disclosed |
| EP-0186522-B1 | CANCER-SPECIFIC DNA | SANKYO COMPANY LIMITED (JP) | 1990-03-14 | — | — | EP | disclosed |
| EP-0351313-A2 | Novel glycoprotein and gene coding therefor | Okada, Hidechika (JP) | 1990-01-17 | — | — | EP | disclosed |
| US-4847081-A | GENETIC ENGINEERING, CLONING | W. R. GRACE & CO.-CONN. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0322084-A2 | Tumor cell inhibition factor | GREEN CROSS CORPORATION (JP) | 1989-06-28 | — | — | EP | disclosed |
| US-4743553-A | Synthetic genes for bovine parainfluenza virus | W. R. GRACE & CO. (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0198645-A1 | Human pancreatic elastase | SANKYO COMPANY LIMITED (JP) | 1986-10-22 | — | — | EP | disclosed |
| EP-0186522-A1 | Cancer-specific DNA | SANKYO COMPANY LIMITED (JP) | 1986-07-02 | — | — | EP | disclosed |
| EP-0157604-A2 | Porcine pancreatic elastase | SANKYO COMPANY LIMITED (JP) | 1985-10-09 | — | — | EP | disclosed |