Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.36 |
| ▸ | VHL | P40337 | 1/20 | 0.34 |
| ▸ | ELOC | Q15369 | 1/20 | 0.34 |
| ▸ | ELOB | Q15370 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757690 | 0.78 | SLC5A2 (0.42) | LMNAMAPTSLC5A2VHLELOC | |
| SCHEMBL14172986 | 0.78 | CTSL (0.46) | LMNAMAPTSLC5A2VHLELOC | |
| SCHEMBL1861656 | 0.76 | AKR1B1 (0.50) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL25569782 | 0.75 | AKR1B1 (0.36) | LMNAMAPTSLC5A2SLC6A4ALDH1A1 | |
| SCHEMBL4824838 | 0.74 | ALDH1A1 (0.40) | MAPTVHLELOCELOBSLC6A4 | |
| SCHEMBL6242819 | 0.74 | SLC6A4 (0.38) | LMNAMAPTSLC5A2VHLELOC | |
| SCHEMBL25569512 | 0.72 | HTR1A (0.36) | LMNAMAPTSLC5A2SLC6A4ALDH1A1 | |
| SCHEMBL25569783 | 0.72 | LMNA (0.35) | LMNAMAPTSLC5A2SLC6A4ALDH1A1 | |
| SCHEMBL1863391 | 0.71 | ALDH1A1 (0.47) | MAPTSLC6A4ALDH1A1 | |
| SCHEMBL27765592 | 0.71 | CYP3A4 (0.49) | LMNAMAPTSLC5A2SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015101928-A1 | FUSED THIOPHENE AND THIAZOLE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-09 | — | — | WO | disclosed |
| EP-2046755-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. Hoffmann-Roche AG (CH) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008012227-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-31 | — | — | WO | disclosed |