Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.66 |
| ▸ | CSF1R | P07333 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934672 | 0.90 | BRAF (1.00) | BRAFCYP2C9CSF1R | |
| SCHEMBL3934910 | 0.89 | BRAF (0.81) | BRAFCYP2C9CSF1R | |
| SCHEMBL3939789 | 0.87 | BRAF (0.75) | BRAFCYP2C9CSF1R | |
| SCHEMBL3937125 | 0.86 | CSF1R (0.79) | BRAFCSF1R | |
| SCHEMBL22364998 | 0.86 | BRAF (0.89) | BRAFCYP2C9CSF1R | |
| SCHEMBL3935559 | 0.82 | BRAF (0.80) | BRAFCSF1R | |
| SCHEMBL3931363 | 0.82 | CSF1R (0.80) | BRAFCSF1R | |
| SCHEMBL3944890 | 0.81 | CSF1R (0.78) | BRAFCSF1R | |
| SCHEMBL3936478 | 0.81 | CSF1R (0.81) | BRAFCSF1R | |
| SCHEMBL3943528 | 0.81 | BRAF (0.80) | BRAFCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |