Sugi Predict

Sugi Predict / Compounds / SCHEMBL3940201

SCHEMBL3940201

SCHEMBL3940201

CC(=O)c1ccc(OC(C)C)c(Cl)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 4/20 0.65
▸ ALDH1A1 P00352 4/20 0.52
▸ TSHR P16473 1/20 0.52
▸ CSNK2A1 P68400 2/20 0.50
▸ MEN1 O00255 1/20 0.50
▸ PKM P14618 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ POLB P06746 1/20 0.50
▸ ESRRA P11474 1/20 0.48
▸ MRGPRX4 Q96LA9 1/20 0.48
▸ KMO O15229 2/20 0.47
▸ ADRB2 P07550 1/20 0.46
▸ CENPE Q02224 1/20 0.46
▸ PDK1 Q15118 1/20 0.44
▸ MAPT P10636 2/20 0.44
▸ HPGD P15428 1/20 0.43
▸ HTT P42858 1/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL403840 0.86 RORC (0.56) RORCALDH1A1TSHRCSNK2A1MEN1
SCHEMBL1014238 0.86 RORC (0.56) RORCCSNK2A1MEN1KMT2AKMO
SCHEMBL16951316 0.86 RORC (0.55) RORCALDH1A1TSHRCSNK2A1MEN1
SCHEMBL25139527 0.85 RORC (0.55) RORCALDH1A1TSHRCSNK2A1MEN1
SCHEMBL2282127 0.85 MAPT (0.52) RORCALDH1A1MEN1KMT2APOLB
SCHEMBL2104888 0.85 RORC (0.55) RORCALDH1A1CSNK2A1MEN1KMT2A
SCHEMBL1015712 0.83 RORC (0.57) RORCALDH1A1CSNK2A1MEN1KMT2A
SCHEMBL1980673 0.83 CA12 (0.54) RORCALDH1A1CSNK2A1MEN1KMT2A
SCHEMBL2104049 0.81 RORC (0.55) RORCALDH1A1CSNK2A1MEN1KMT2A
SCHEMBL30628216 0.81 ALDH1A1 (0.57) RORCALDH1A1TSHRMEN1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111170991-B Antiproliferative compounds and methods of synthesis thereof 细胞基因公司 2023-10-31 — — CN disclosed
EP-3594211-B1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2023-10-25 — — EP disclosed
US-20230121337-A1 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS, INC. 2023-04-20 — — US disclosed
WO-2022272106-A1 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS, INC. (US) 2022-12-29 — — WO disclosed
US-20220387413-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2022-12-08 — — US disclosed
US-11241423-B2 Antiproliferative compounds and methods of use thereof CELGENE CORPORATION (US) 2022-02-08 — — US disclosed
US-20200163948-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2020-05-28 — — US disclosed
EP-3166937-B1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2019-09-04 — — EP disclosed
US-20180221361-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2018-08-09 — — US disclosed
US-9968596-B2 Antiproliferative compounds and methods of use thereof CELGENE CORPORATION (US) 2018-05-15 — — US disclosed
US-20150203511-A1 TETRAZOLINONE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-07-23 — — US disclosed
US-20150203511-A1 TETRAZOLINONE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-07-23 — — US disclosed
US-20150203511-A1 TETRAZOLINONE COMPOUNDS AND THEIR USE AS PESTICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-07-23 — — US disclosed
WO-2014192953-A1 TETRAZOLINONE COMPOUND AND APPLICATION OF SAME 住友化学株式会社 (JP) 2014-12-04 — — WO disclosed
US-20090069288-A1 Novel therapeutic compounds ABBVIE INC. 2009-03-12 — — US disclosed
US-20090069288-A1 Novel therapeutic compounds ABBVIE INC. 2009-03-12 — — US disclosed
US-20090069288-A1 Novel therapeutic compounds ABBVIE INC. 2009-03-12 — — US disclosed
WO-2009011850-A2 NOVEL THERAPEUTIC COMPOUNDS ABBOTT LABORATORIES (US) 2009-01-22 — — WO disclosed
WO-2009011850-A2 NOVEL THERAPEUTIC COMPOUNDS ABBOTT LABORATORIES (US) 2009-01-22 — — WO disclosed
WO-2007056469-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS CYTOKINETICS, INC. (US) 2007-05-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220387413-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF MCL1, MKI67, BAX RORC 1517/4885ALDH1A1 247/4885TSHR 4516/4885
US-20230121337-A1 CDK2 INHIBITORS AND METHODS OF USING THE SAME CDK2, CDK20, CDK2AP2 RORC 1675/4885ALDH1A1 3716/4885TSHR 3996/4885
US-11241423-B2 Antiproliferative compounds and methods of use thereof MCL1, MKI67, BAX RORC 1517/4885ALDH1A1 247/4885TSHR 4516/4885
US-20200163948-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF MCL1, MKI67, BAX RORC 1517/4885ALDH1A1 247/4885TSHR 4516/4885
US-20150203511-A1 TETRAZOLINONE COMPOUNDS AND THEIR USE AS PESTICIDES CYCS, MT-CO3, CYP4F11 RORC 1064/4885ALDH1A1 1436/4885TSHR 125/4885
US-20090069288-A1 Novel therapeutic compounds MAP3K20, RPS6KB1, MAP3K1 RORC 222/4885ALDH1A1 1426/4885TSHR 4278/4885
US-20180221361-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF MCL1, MKI67, BAX RORC 1517/4885ALDH1A1 247/4885TSHR 4516/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.