Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.44 |
| ▸ | LIPE | Q05469 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.42 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.42 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.42 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10848575 | 0.86 | MRGPRX4 (0.49) | MRGPRX4L3MBTL1RAB9ALMNAKMT2A | |
| SCHEMBL4688851 | 0.86 | KMT2A (0.51) | MRGPRX4L3MBTL1RAB9ALMNAKMT2A | |
| SCHEMBL8501956 | 0.86 | LMNA (0.60) | RAB9ALMNALIPEPLAAT3PLAAT5 | |
| SCHEMBL13506423 | 0.85 | HPGD (0.66) | MRGPRX4L3MBTL1RAB9ALMNAKMT2A | |
| SCHEMBL20808089 | 0.84 | MRGPRX4 (0.56) | MRGPRX4L3MBTL1RAB9ALMNAKMT2A | |
| SCHEMBL8466775 | 0.82 | LIPE (0.51) | MRGPRX4RAB9ALMNALIPEHPGD | |
| SCHEMBL5080403 | 0.80 | MRGPRX4 (0.48) | MRGPRX4L3MBTL1RAB9ALMNAKMT2A | |
| SCHEMBL831499 | 0.80 | MRGPRX4 (0.48) | MRGPRX4L3MBTL1RAB9ALMNAKMT2A | |
| SCHEMBL5764034 | 0.80 | HPGD (0.46) | MRGPRX4L3MBTL1RAB9ALMNAKMT2A | |
| SCHEMBL5076062 | 0.79 | MRGPRX4 (0.47) | MRGPRX4L3MBTL1RAB9ALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2019593-A1 | PRO-DRUGS OF TERTIARY ALCOHOLS | Merck & Co., Inc. (US) | 2009-02-04 | — | — | EP | disclosed |
| US-7348456-B2 | Substituted amides | MERCK & CO., INC. (US) | 2008-03-25 | — | — | US | disclosed |
| WO-2007136571-A1 | PRO-DRUGS OF TERTIARY ALCOHOLS | MERCK & CO., INC. (US) | 2007-11-29 | — | — | WO | disclosed |
| US-20060106071-A1 | Substituted amides | MERCK SHARP & DOHME CORP. | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106071-A1 | Substituted amides | CNR1, CNR2, FAAH | MRGPRX4 83/4885L3MBTL1 3168/4885RAB9A 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.