Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326852 | 0.98 | LMNA (0.35) | LMNAL3MBTL1KMT2APABPC1ATM | |
| SCHEMBL9622357 | 0.79 | PABPC1 (0.36) | LMNAL3MBTL1PABPC1MAPTRAD52 | |
| SCHEMBL9622709 | 0.78 | PABPC1 (0.35) | LMNAL3MBTL1PABPC1HTTKDM4E | |
| SCHEMBL2320677 | 0.76 | HDAC8 (0.47) | — | |
| SCHEMBL2330418 | 0.76 | HDAC8 (0.47) | KMT2AGGPS1 | |
| SCHEMBL13865850 | 0.76 | ALDH1A1 (0.32) | KMT2APABPC1ATMHTTALDH1A1 | |
| SCHEMBL2320516 | 0.74 | LMNA (0.42) | LMNAL3MBTL1KMT2AMEN1HTT | |
| SCHEMBL28331251 | 0.74 | NQO1 (0.43) | LMNAKMT2AMEN1MAPK1SMN1; SMN2 | |
| SCHEMBL28093261 | 0.74 | MAPK1 (0.32) | KMT2APABPC1ATMMAPK1GGPS1 | |
| SCHEMBL2327067 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009011904-A1 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |