Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.80 |
| ▸ | CSF1R | P07333 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942646 | 0.90 | BRAF (0.83) | BRAFCSF1RALDH1A1RAB9A | |
| SCHEMBL3935730 | 0.89 | BRAF (1.00) | BRAFCSF1RALDH1A1NPC1RAB9A | |
| SCHEMBL4165366 | 0.85 | MAPK1 (0.81) | BRAFCSF1RALDH1A1NPC1RAB9A | |
| SCHEMBL3937779 | 0.85 | BRAF (1.00) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3942233 | 0.84 | BRAF (1.00) | BRAFCSF1RALDH1A1KITKDR | |
| SCHEMBL6014511 | 0.84 | ALDH1A1 (0.72) | BRAFCSF1RALDH1A1NPC1TP53 | |
| SCHEMBL3944151 | 0.83 | BRAF (0.77) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3945794 | 0.83 | BRAF (0.80) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL1276903 | 0.83 | BRAF (1.00) | BRAFCSF1R | |
| SCHEMBL3942520 | 0.83 | BRAF (1.00) | BRAFCSF1RKITKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |